A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.
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Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway DiseasesA Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipidCellular functions of TMEM16/anoctaminCalmodulin regulation of TMEM16A and 16B Ca(2+)-activated chloride channelsVariomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation.Modulating Ca²⁺ signals: a common theme for TMEM16, Ist2, and TMC.Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels.Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons.Identification of a lipid scrambling domain in ANO6/TMEM16F.Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex.Two helices in the third intracellular loop determine anoctamin 1 (TMEM16A) activation by calciumA novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2.Permeation Mechanisms in the TMEM16B Calcium-Activated Chloride Channels.Independent activation of distinct pores in dimeric TMEM16A channelsTMEM16 chloride channels are two-faced.TMEM16 proteins: unknown structure and confusing functions.Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistanceTMEM16A/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2/ERBB2.Influence of intracellular Ca2+ and alternative splicing on the pharmacological profile of ANO1 channels.Revealing the activation pathway for TMEM16A chloride channels from macroscopic currents and kinetic models.Two Ca(2+)-Binding Sites Cooperatively Couple Together in TMEM16A Channel.New Insights on the Regulation of Ca2+ -Activated Chloride Channel TMEM16A.Ginsenoside Rb1, a novel activator of the TMEM16A chloride channel, augments the contraction of guinea pig ileum.Molecular, biophysical, and pharmacological properties of calcium-activated chloride channels.Molecular simulation assisted identification of Ca(2+) binding residues in TMEM16A.Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16ALipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase.Intermolecular Interactions in the TMEM16A Dimer Controlling Channel ActivityPurified human brain calmodulin does not alter the bicarbonate permeability of the ANO1/TMEM16A channel.Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A).Cryo-EM structures of the TMEM16A calcium-activated chloride channel.Highlights for the 6th International Ion Channel Conference: ion channel structure, function, disease and therapeutics.Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM.Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F.Extracellular protons enable activation of the calcium-dependent chloride channel TMEM16A.EAVK segment "c" sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1.Functional roles of glutamic acid E143 and E705 residues in the N-terminus and transmembrane domain 7 of Anoctamin 1 in calcium and noxious heat sensing.Anoctamins/TMEM16 Proteins: Chloride Channels Flirting with Lipids and Extracellular Vesicles.Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B.Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases.
P2860
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P2860
A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.
description
2014 nî lūn-bûn
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2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2014 թվականի հունիսին հրատարակված գիտական հոդված
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年學術文章
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name
A comprehensive search for cal ...... ted chloride channel activity.
@ast
A comprehensive search for cal ...... ted chloride channel activity.
@en
type
label
A comprehensive search for cal ...... ted chloride channel activity.
@ast
A comprehensive search for cal ...... ted chloride channel activity.
@en
prefLabel
A comprehensive search for cal ...... ted chloride channel activity.
@ast
A comprehensive search for cal ...... ted chloride channel activity.
@en
P2093
P2860
P356
P1433
P1476
A comprehensive search for cal ...... ated chloride channel activity
@en
P2093
Christian J Peters
Jason Tien
Lily Yeh Jan
Tong Cheng
Yuh Nung Jan
P2860
P356
10.7554/ELIFE.02772
P407
P577
2014-06-30T00:00:00Z