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In vitro assay using engineered yeast vacuoles for neuronal SNARE-mediated membrane fusion.Studying protein-reconstituted proteoliposome fusion with content indicators in vitro.Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission.The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosisSynaptic proteins promote calcium-triggered fast transition from point contact to full fusion.Membrane fusion intermediates via directional and full assembly of the SNARE complex.Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter release.Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins.Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion.SM protein Munc18-2 facilitates transition of Syntaxin 11-mediated lipid mixing to complete fusion for T-lymphocyte cytotoxicity.A cascade of multiple proteins and lipids catalyzes membrane fusion.Physiological lipid composition is vital for homotypic ER membrane fusion mediated by the dynamin-related GTPase Sey1p.Mechanism of neurotransmitter release coming into focus
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Membrane bridging and hemifusion by denaturated Munc18.
@ast
Membrane bridging and hemifusion by denaturated Munc18.
@en
type
label
Membrane bridging and hemifusion by denaturated Munc18.
@ast
Membrane bridging and hemifusion by denaturated Munc18.
@en
prefLabel
Membrane bridging and hemifusion by denaturated Munc18.
@ast
Membrane bridging and hemifusion by denaturated Munc18.
@en
P2093
P2860
P1433
P1476
Membrane bridging and hemifusion by denaturated Munc18.
@en
P2093
Alpay B Seven
Qiu-Xing Jiang
P2860
P304
P356
10.1371/JOURNAL.PONE.0022012
P407
P50
P577
2011-07-06T00:00:00Z