Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease. - Wikidata - wikimedia - TriplyDB

Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease.

Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease.

http://www.wikidata.org/entity/Q33964297

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Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium Evidence for the involvement of lipid rafts localized at the ER-mitochondria associated membranes in autophagosome formation.Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL Computational modeling of sphingolipid metabolism.Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex.Quercetin protects human brain microvascular endothelial cells from fibrillar β-amyloid1-40-induced toxicity Glycosphingolipids and cell death: one aim, many ways TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy and reduces renal dysfunction in a cyclosporine A-induced nephrotoxicity model Crystal structure of mammalian acid sphingomyelinase Essential role for acid sphingomyelinase-inhibited autophagy in melanoma response to cisplatin.The emerging role of acid sphingomyelinase in autophagy.Autophagic flux and autophagosome morphogenesis require the participation of sphingolipids.Role of sphingomyelinases in neurological disorders.Ceramide and Its Related Neurochemical Networks as Targets for Some Brain Disorder Therapies.Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease.Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease.Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy.Modulation of Neuroinflammation in the Central Nervous System: Role of Chemokines and Sphingolipids.Autophagy and Alzheimer's Disease.Induced pluripotent stem cell technology: a decade of progress.Omega-3 fatty acids, lipids and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention.ASM in Alzheimer's disease.Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis.Inhibition of Acid Sphingomyelinase Disrupts LYNUS Signaling and Triggers Autophagy.Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.Autophagy in Stem Cell Biology: A Perspective on Stem Cell Self-Renewal and Differentiation.The effects of treadmill exercise on autophagy in hippocampus of APP/PS1 transgenic mice.Activation of neutral sphingomyelinase 2 by starvation induces cell-protective autophagy via an increase in Golgi-localized ceramide.Role of sphingolipids in senescence: implication in aging and age-related diseases A novel effect of ethyl pyruvate in Schwann cell de-differentiation and proliferation during Wallerian degeneration

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Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease.

http://www.wikidata.org/entity/Q33964297

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2014 nî lūn-bûn

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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2014 թվականի հուլիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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Acid sphingomyelinase modulate ...... enesis in Alzheimer's disease.

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Bo-ra Kim

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Edward H Schuchman

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Hee Kyung Jin

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Hiromitsu Nakauchi

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Jae-sung Bae

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Janet E Carter

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Jong Kil Lee

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Min Hee Park

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Phil Hyu Lee

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Xingxuan He

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P2860

Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

Generation of germline-competent induced pluripotent stem cells

Alzheimer's disease: genes, proteins, and therapy

Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

TFEB links autophagy to lysosomal biogenesis

Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.

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Alzheimer's disease

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4113944

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