Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase.
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Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stabilityIdentification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partnerCrystal structures of Escherichia coli ATP-dependent glucokinase and its complex with glucoseASD: a comprehensive database of allosteric proteins and modulatorsMolecular physiology of mammalian glucokinaseEnzymes: principles and biotechnological applicationsHomotropic allosteric regulation in monomeric mammalian glucokinaseCooperativity in monomeric enzymes with single ligand-binding sitesSynergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis.Conformational transition pathway in the activation process of allosteric glucokinaseDynamic localization of glucokinase and its regulatory protein in hypothalamic tanycytesCrystal structures of an ATP-dependent hexokinase with broad substrate specificity from the hyperthermophilic archaeon Sulfolobus tokodaiiStructure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stabilityCrystal structure of E339K mutated human glucokinase reveals changes in the ATP binding siteEngineering an allosteric binding site for aminoglycosides into TEM1-β-LactamaseThe active conformation of human glucokinase is not altered by allosteric activatorsSubstrate Recognition Mechanism and Substrate-Dependent Conformational Changes of an ROK Family Glucokinase from Streptomyces griseusInsights into Mechanism of Glucokinase ActivationMolecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinaseStructural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory ProteinX-ray crystallographic studies of family 11 xylanase Michaelis and product complexes: implications for the catalytic mechanismBiochemical and structural study of Arabidopsis hexokinase 1Glucokinase gene mutations: structural and genotype-phenotype analyses in MODY children from South ItalyFunctional characterization of MODY2 mutations highlights the importance of the fine-tuning of glucokinase and its role in glucose sensingA panel of diverse assays to interrogate the interaction between glucokinase and glucokinase regulatory protein, two vital proteins in human diseaseSequence analysis and molecular characterization of Clonorchis sinensis hexokinase, an unusual trimeric 50-kDa glucose-6-phosphate-sensitive allosteric enzymeAdvanced enzymology, expression profile and immune response of Clonorchis sinensis hexokinase show its application potential for prevention and control of clonorchiasisSmall molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humansAn allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolismThe origin and evolution of ribonucleotide reductionEvolution- and structure-based computational strategy reveals the impact of deleterious missense mutations on MODY 2 (maturity-onset diabetes of the young, type 2)Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis.Structure-based predictive models for allosteric hot spots.Ligand depletion in vivo modulates the dynamic range and cooperativity of signal transduction.Comparative docking assessment of glucokinase interactions with its allosteric activatorsArtocarpus communis Forst. root-bark aqueous extract- and streptozotocin-induced ultrastructural and metabolic changes in hepatic tissues of Wistar ratsOpposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene.Human 60-kDa lysophospholipase contains an N-terminal L-asparaginase domain that is allosterically regulated by L-asparagine.Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody.Glucokinase activators (GKAs) promise a new pharmacotherapy for diabetics.
P2860
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P2860
Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase.
description
2004 nî lūn-bûn
@nan
2004 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մարտին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Structural basis for allosteri ...... eric enzyme human glucokinase.
@ast
Structural basis for allosteri ...... eric enzyme human glucokinase.
@en
type
label
Structural basis for allosteri ...... eric enzyme human glucokinase.
@ast
Structural basis for allosteri ...... eric enzyme human glucokinase.
@en
prefLabel
Structural basis for allosteri ...... eric enzyme human glucokinase.
@ast
Structural basis for allosteri ...... eric enzyme human glucokinase.
@en
P2093
P1433
P1476
Structural basis for allosteri ...... eric enzyme human glucokinase.
@en
P2093
Jun-Ichi Eiki
Kenji Kamata
Morihiro Mitsuya
Teruyuki Nishimura
Yasufumi Nagata
P304
P356
10.1016/J.STR.2004.02.005
P577
2004-03-01T00:00:00Z