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Resurrecting ancient genes: experimental analysis of extinct molecules.

Resurrecting ancient genes: experimental analysis of extinct molecules.

http://www.wikidata.org/entity/Q33978298

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Evolution of minimal specificity and promiscuity in steroid hormone receptors Assessing the accuracy of ancestral protein reconstruction methods Exploiting models of molecular evolution to efficiently direct protein engineering Crystal structure of an ancient protein: evolution by conformational epistasis The ancient mariner sails again: transposition of the human Hsmar1 element by a reconstructed transposase and activities of the SETMAR protein on transposon ends Consensus protein design Experimental macroevolution Urzymology: experimental access to a key transition in the appearance of enzymes Experimental approaches to evaluate the contributions of candidate protein-coding mutations to phenotypic evolution Allosteric activation transitions in enzymes and biomolecular motors: insights from atomistic and coarse-grained simulations An experimental phylogeny to benchmark ancestral sequence reconstruction An epistatic ratchet constrains the direction of glucocorticoid receptor evolution Mechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid Receptor Experimental evidence for the thermophilicity of ancestral life X-Ray Crystal Structure of the Ancestral 3-Ketosteroid Receptor–Progesterone–Mifepristone Complex Shows Mifepristone Bound at the Coactivator Binding Interface Vestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Hormone Receptor Plant synthetic biology for molecular engineering of signalling and development Resurrecting ancestral alcohol dehydrogenases from yeast Analyzing protein structure and function using ancestral gene reconstruction Reconstructing large regions of an ancestral mammalian genome in silico PhyloBot: A Web Portal for Automated Phylogenetics, Ancestral Sequence Reconstruction, and Exploration of Mutational Trajectories Evolutionary history of versatile-lipases from Agaricales through reconstruction of ancestral structures Evolutionary diversification of retinoic acid receptor ligand-binding pocket structure by molecular tinkering Rapid bursts and slow declines: on the possible evolutionary trajectories of enzymes A Cambrian origin for vertebrate rods Experimental evolution of protein-protein interaction networks Molecular evolution and the latitudinal biodiversity gradient Single-molecule paleoenzymology probes the chemistry of resurrected enzymes Genome digging: insight into the mitochondrial genome of Homo Origin of INSL3-mediated testicular descent in therian mammals Mechanistic approaches to the study of evolution: the functional synthesis Robustness of Ancestral Sequence Reconstruction to Phylogenetic Uncertainty Evolution of increased complexity in a molecular machine Selection on protein structure, interaction, and sequence.Structural reconstruction of protein ancestry.Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors.An evaluation of phylogenetic methods for reconstructing transmitted HIV variants using longitudinal clonal HIV sequence data.Exploring divergent antibiotic resistance genes in ancient metagenomes and discovery of a novel beta-lactamase family.Diversification and specialization of HIV protease function during in vitro evolution.Application of DETECTER, an evolutionary genomic tool to analyze genetic variation, to the cystic fibrosis gene family.

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P2860

Resurrecting ancient genes: experimental analysis of extinct molecules.

http://www.wikidata.org/entity/Q33978298

description

2004 nî lūn-bûn

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2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2004 թվականի մայիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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Resurrecting ancient genes: experimental analysis of extinct molecules.

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Resurrecting ancient genes: experimental analysis of extinct molecules.

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Resurrecting ancient genes: experimental analysis of extinct molecules.

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Resurrecting ancient genes: experimental analysis of extinct molecules.

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Nature Reviews Genetics

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Resurrecting ancient genes: experimental analysis of extinct molecules.

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Joseph W Thornton

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P2860

Microbial genetics: Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation

A fast algorithm for joint reconstruction of ancestral amino acid sequences

Planetary biology--paleontological, geological, and molecular histories of life

Reconstructing the evolutionary history of the artiodactyl ribonuclease superfamily

Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells

The structural basis of molecular adaptation.

Rapid evolution in plant chitinases: molecular targets of selection in plant-pathogen coevolution.

Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions.

Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling.

Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates.

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366-375

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scholarly article

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10.1038/NRG1324

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5

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5

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1043040407

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15143319

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