Plk1-targeted small molecule inhibitors: molecular basis for their potency and specificity.
about
PLK-1 Targeted Inhibitors and Their Potential against TumorigenesisExploring the Binding Nature of Pyrrolidine Pocket-Dependent Interactions in the Polo-Box Domain of Polo-Like Kinase 1Dynamic and multi-pharmacophore modeling for designing polo-box domain inhibitorsDesign and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1RNAi screen identifies a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibitionProteomic identification of novel cytoskeletal proteins associated with TbPLK, an essential regulator of cell morphogenesis in Trypanosoma bruceiIdentification of a novel Polo-like kinase 1 inhibitor that specifically blocks the functions of Polo-Box domainChemical visualization of phosphoproteomes on membrane.Validation of Polo-like kinase 1 as a therapeutic target in pancreatic cancer cellsUnderstanding the Polo Kinase machine.The hunt for antimitotic agents: an overview of structure-based design strategies.Identification of green tea catechins as potent inhibitors of the polo-box domain of polo-like kinase 1.p53-Dependent and cell specific epigenetic regulation of the polo-like kinases under oxidative stress.Polo-like kinase 1 inhibition causes decreased proliferation by cell cycle arrest, leading to cell death in glioblastoma.Identification of novel kinase inhibitors by targeting a kinase-related apoptotic protein-protein interaction network in HeLa cells.RNAi-mediated knockdown of MCM7 gene on CML cells and its therapeutic potential for leukemia.TS-Chemscore, a Target-Specific Scoring Function, Significantly Improves the Performance of Scoring in Virtual Screening.Design, synthesis, and evaluation of non-ATP-competitive small-molecule Polo-like kinase 1 (Plk1) inhibitors.
P2860
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P2860
Plk1-targeted small molecule inhibitors: molecular basis for their potency and specificity.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年學術文章
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name
Plk1-targeted small molecule i ...... their potency and specificity.
@ast
Plk1-targeted small molecule i ...... their potency and specificity.
@en
type
label
Plk1-targeted small molecule i ...... their potency and specificity.
@ast
Plk1-targeted small molecule i ...... their potency and specificity.
@en
prefLabel
Plk1-targeted small molecule i ...... their potency and specificity.
@ast
Plk1-targeted small molecule i ...... their potency and specificity.
@en
P2093
P2860
P1433
P1476
Plk1-targeted small molecule i ...... their potency and specificity.
@en
P2093
Chaejoon Cheong
Eun-Hee Kim
Jeong Kyu Bang
Jung-Eun Park
Kyung S Lee
Ravichandran N Murugan
Song Yub Shin
P2860
P2888
P304
P356
10.1007/S10059-011-0126-3
P577
2011-07-29T00:00:00Z