Attenuation of Marek's disease virus by deletion of open reading frame RLORF4 but not RLORF5a
about
Herpesvirus telomeric repeats facilitate genomic integration into host telomeres and mobilization of viral DNA during reactivationMicroRNA profile of Marek's disease virus-transformed T-cell line MSB-1: predominance of virus-encoded microRNAsHerpesvirus telomerase RNA(vTR)-dependent lymphoma formation does not require interaction of vTR with telomerase reverse transcriptase (TERT).Characterizing the molecular basis of attenuation of Marek's disease virus via in vitro serial passage identifies de novo mutations in the helicase-primase subunit gene UL5 and other candidates associated with reduced virulence.Viral control of vTR expression is critical for efficient formation and dissemination of lymphoma induced by Marek's disease virus (MDV).Further analysis of Marek's disease virus horizontal transmission confirms that U(L)44 (gC) and U(L)13 protein kinase activity are essential, while U(S)2 is nonessential.Herpesvirus telomerase RNA (vTR) with a mutated template sequence abrogates herpesvirus-induced lymphomagenesis.Dual infection and superinfection inhibition of epithelial skin cells by two alphaherpesviruses co-occur in the natural host.Deletion of the Meq gene significantly decreases immunosuppression in chickens caused by pathogenic Marek's disease virusMarek's disease virus encodes MicroRNAs that map to meq and the latency-associated transcriptIn vitro model for lytic replication, latency, and transformation of an oncogenic alphaherpesvirus.Fluorescently tagged pUL47 of Marek's disease virus reveals differential tissue expression of the tegument protein in vivoHorizontal transmission of Marek's disease virus requires US2, the UL13 protein kinase, and gCMarek's disease virus expresses multiple UL44 (gC) variants through mRNA splicing that are all required for efficient horizontal transmission.A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis.A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation.ESCDL-1, a new cell line derived from chicken embryonic stem cells, supports efficient replication of Mardiviruses.Marek's disease virus: lytic replication, oncogenesis and control.Marek's disease virus late protein expression in feather follicle epithelial cells as early as 8 days postinfectionMarek's disease virus-encoded microRNAs: genomics, expression and function.Putative roles as oncogene or tumour suppressor of the Mid-clustered microRNAs in Gallid alphaherpesvirus 2 (GaHV2) induced Marek's disease lymphomagenesis.Interindividual Spread of Herpesviruses.Telomeres and Telomerase: Role in Marek's Disease Virus Pathogenesis, Integration and Tumorigenesis.Comparative full-length sequence analysis of Marek's disease virus vaccine strain 814.Molecular and pathogenicity characterization of Gallid herpesvirus 2 newly isolated in China from 2009 to 2013.The ORF012 gene of Marek's disease virus type 1 produces a spliced transcript and encodes a novel nuclear phosphoprotein essential for virus growth.Role of the short telomeric repeat region in Marek's disease virus replication, genomic integration, and lymphomagenesis.Marek's disease viral interleukin-8 promotes lymphoma formation through targeted recruitment of B cells and CD4+ CD25+ T cellsSelf-excision of the BAC sequences from the recombinant Marek's disease virus genome increases replication and pathogenicity.A phylogenomic analysis of Marek's disease virus reveals independent paths to virulence in Eurasia and North America.Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimization.Identification of the Receptor and Cellular Ortholog of the Marek's Disease Virus (MDV) CXC Chemokine.Epstein-Barr virus-encoded RNAs (EBERs) complement the loss of Herpesvirus telomerase RNA (vTR) in virus-induced tumor formation.Dynamic equilibrium of Marek's disease genomes during in vitro serial passage.Atrophy of primary lymphoid organs induced by Marek's disease virus during early infection is associated with increased apoptosis, inhibition of cell proliferation and a severe B-lymphopenia.Application of CRISPR/Cas9 Gene Editing System on MDV-1 Genome for the Study of Gene Function
P2860
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P2860
Attenuation of Marek's disease virus by deletion of open reading frame RLORF4 but not RLORF5a
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Attenuation of Marek's disease ...... g frame RLORF4 but not RLORF5a
@ast
Attenuation of Marek's disease ...... g frame RLORF4 but not RLORF5a
@en
type
label
Attenuation of Marek's disease ...... g frame RLORF4 but not RLORF5a
@ast
Attenuation of Marek's disease ...... g frame RLORF4 but not RLORF5a
@en
prefLabel
Attenuation of Marek's disease ...... g frame RLORF4 but not RLORF5a
@ast
Attenuation of Marek's disease ...... g frame RLORF4 but not RLORF5a
@en
P2860
P50
P1433
P1476
Attenuation of Marek's disease ...... g frame RLORF4 but not RLORF5a
@en
P2093
Karel A Schat
P2860
P304
11647-11659
P356
10.1128/JVI.79.18.11647-11659.2005
P407
P577
2005-09-01T00:00:00Z