The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration.
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Thiamin diphosphate-dependent enzymes: from enzymology to metabolic regulation, drug design and disease modelsThe novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase.Multiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological ImplicationsMild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's diseaseLipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathwayActivation of double-stranded RNA-activated protein kinase by mild impairment of oxidative metabolism in neuronsNovel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heartMitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition.Reporter pathway analysis from transcriptome data: Metabolite-centric versus Reaction-centric approach.Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer's Disease.The role of mitochondria in reactive oxygen species metabolism and signaling.Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.Genome-wide analysis of Saccharomyces cerevisiae identifies cellular processes affecting intracellular aggregation of Alzheimer's amyloid-β42: importance of lipid homeostasis.Glutathionylation of α-ketoglutarate dehydrogenase: the chemical nature and relative susceptibility of the cofactor lipoic acid to modification.Behavioral impact of the regulation of the brain 2-oxoglutarate dehydrogenase complex by synthetic phosphonate analog of 2-oxoglutarate: implications into the role of the complex in neurodegenerative diseases.ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics.Brain pyruvate and 2-oxoglutarate dehydrogenase complexes are mitochondrial targets of the CoA ester of the Refsum disease marker phytanic acid.Neuroprotective strategies involving ROS in Alzheimer disease.Ethanol promotes thiamine deficiency-induced neuronal death: involvement of double-stranded RNA-activated protein kinase.Mitochondria and antioxidant targeted therapeutic strategies for Alzheimer's disease.Metabolic control exerted by the 2-oxoglutarate dehydrogenase reaction: a cross-kingdom comparison of the crossroad between energy production and nitrogen assimilation.Systematic analysis of transcription-level effects of neurodegenerative diseases on human brain metabolism by a newly reconstructed brain-specific metabolic networkThiamine deficiency induces endoplasmic reticulum stress in neurons.Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease.Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment.Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesions.White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease.A survey of oxidative paracatalytic reactions catalyzed by enzymes that generate carbanionic intermediates: implications for ROS production, cancer etiology, and neurodegenerative diseases.Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathwaysOxidative stress and transcriptional regulation in Alzheimer diseaseClinical implications from proteomic studies in neurodegenerative diseases: lessons from mitochondrial proteins.Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner.The effect of chronic tianeptine administration on the brain mitochondria: direct links with an animal model of depression.Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model.Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.Potential For Cell-mediated Immune Responses In Mouse Models Of Pelizaeus-Merzbacher Disease.Lipoic acid: energy metabolism and redox regulation of transcription and cell signalingBrain activation of SIRT1: role in neuropathology.Oleuropein isolated from Fraxinus rhynchophylla inhibits glutamate-induced neuronal cell death by attenuating mitochondrial dysfunction.A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.
P2860
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P2860
The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The alpha-ketoglutarate-dehydr ...... e stress in neurodegeneration.
@ast
The alpha-ketoglutarate-dehydr ...... e stress in neurodegeneration.
@en
type
label
The alpha-ketoglutarate-dehydr ...... e stress in neurodegeneration.
@ast
The alpha-ketoglutarate-dehydr ...... e stress in neurodegeneration.
@en
prefLabel
The alpha-ketoglutarate-dehydr ...... e stress in neurodegeneration.
@ast
The alpha-ketoglutarate-dehydr ...... e stress in neurodegeneration.
@en
P2093
P356
P1476
The alpha-ketoglutarate-dehydr ...... e stress in neurodegeneration.
@en
P2093
Gary E Gibson
John P Blass
M Flint Beal
Victoria Bunik
P2888
P356
10.1385/MN:31:1-3:043
P577
2005-01-01T00:00:00Z
P5875
P6179
1039732098