Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction
about
Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis.Topical N-acetylcysteine accelerates wound healing in vitro and in vivo via the PKC/Stat3 pathwayIdentification of a central role for complement in osteoarthritis.PKCε signalling activates ERK1/2, and regulates aggrecan, ADAMTS5, and miR377 gene expression in human nucleus pulposus cells.Loss of the polarity protein PAR3 activates STAT3 signaling via an atypical protein kinase C (aPKC)/NF-κB/interleukin-6 (IL-6) axis in mouse mammary cells.Function of the chondrocyte PI-3 kinase-Akt signaling pathway is stimulus dependent.E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress.The pathophysiologic role of the protein kinase Cδ pathway in the intervertebral discs of rabbits and mice: in vitro, ex vivo, and in vivo studiesProtein kinase C delta null mice exhibit structural alterations in articular surface, intra-articular and subchondral compartments.The Proto-oncogene PKCι regulates the alternative splicing of Bcl-x pre-mRNA.Elevated STAT3 Signaling-Mediated Upregulation of MMP-2/9 Confers Enhanced Invasion Ability in Multidrug-Resistant Breast Cancer Cells.Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway.Bovine lactoferricin-induced anti-inflammation is, in part, via up-regulation of interleukin-11 by secondary activation of STAT3 in human articular cartilageRoles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis.Induction of a chloracne phenotype in an epidermal equivalent model by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on aryl hydrocarbon receptor activation and is not reproduced by aryl hydrocarbon receptor knock down.Proteomic analysis of synovial fluid in osteoarthritis using SWATH‑mass spectrometry.Profiling the interactome of protein kinase C ζ by proteomics and bioinformatics.Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation.Glycogen synthase kinase 3 inhibition stimulates human cartilage destruction and exacerbates murine osteoarthritis.Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes.Baicalin Inhibits Human Cervical Cancer Cells by Suppressing Protein Kinase C/Signal Transducer and Activator of Transcription (PKC/STAT3) Signaling Pathway.
P2860
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P2860
Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Protein kinase C isoforms zeta ...... ERK-dependent c-fos induction
@ast
Protein kinase C isoforms zeta ...... ERK-dependent c-fos induction
@en
type
label
Protein kinase C isoforms zeta ...... ERK-dependent c-fos induction
@ast
Protein kinase C isoforms zeta ...... ERK-dependent c-fos induction
@en
prefLabel
Protein kinase C isoforms zeta ...... ERK-dependent c-fos induction
@ast
Protein kinase C isoforms zeta ...... ERK-dependent c-fos induction
@en
P2093
P2860
P356
P1476
Protein kinase C isoforms zeta ...... ERK-dependent c-fos induction
@en
P2093
Andrew D Rowan
Christopher D Macdonald
Gary J Litherland
Jonathon B Catterall
Matt J Barter
Matthew J Farren
Matthew Jefferson
P2860
P304
22414-22425
P356
10.1074/JBC.M110.120121
P407
P577
2010-05-12T00:00:00Z