Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge.
about
Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogensHeterogeneity in tuberculosis pathology, microenvironments and therapeutic responsesTuberculosis vaccine types and timingsAdHu5Ag85A Respiratory Mucosal Boost Immunization Enhances Protection against Pulmonary Tuberculosis in BCG-Primed Non-Human PrimatesImmunogenicity without Efficacy of an Adenoviral Tuberculosis Vaccine in a Stringent Mouse Model for Immunotherapy during TreatmentMonkey models of tuberculosis: lessons learnedThe DosR Regulon Modulates Adaptive Immunity and Is Essential for Mycobacterium tuberculosis Persistence.The contribution of non-human primate models to the development of human vaccinesEvaluation of the Immunogenicity of Mycobacterium bovis BCG Delivered by Aerosol to the Lungs of Macaques.Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosisTuberculosis vaccine development: Shifting focus amid increasing development challenges.Hypoxia Sensing and Persistence Genes Are Expressed during the Intragranulomatous Survival of Mycobacterium tuberculosis.Alternative BCG delivery strategies improve protection against Mycobacterium tuberculosis in non-human primates: Protection associated with mycobacterial antigen-specific CD4 effector memory T-cell populationsAerosol immunisation for TB: matching route of vaccination to route of infectionAcquired immunodeficiencies and tuberculosis: focus on HIV/AIDS and diabetes mellitus.Unique cellular and humoral immunogenicity profiles generated by aerosol, intranasal, or parenteral vaccination in rhesus macaques.The mc2-CMX vaccine induces an enhanced immune response against Mycobacterium tuberculosis compared to Bacillus Calmette-Guérin but with similar lung inflammatory effects.LAG-3 potentiates the survival of Mycobacterium tuberculosis in host phagocytes by modulating mitochondrial signaling in an in-vitro granuloma model.Expression and role of VLA-1 in resident memory CD8 T cell responses to respiratory mucosal viral-vectored immunization against tuberculosis.Translational Research in the Nonhuman Primate Model of Tuberculosis.Safety and Immunogenicity of Adenovirus 35 Tuberculosis Vaccine Candidate in Adults with Active or Previous Tuberculosis. A Randomized Trial.Non-pathological infection of macaques by an attenuated mycobacterial vaccine is not reactivated in the setting of HIV coinfection.Intranasal Vaccination with Mannosylated Chitosan Formulated DNA Vaccine Enables Robust IgA and Cellular Response Induction in the Lungs of Mice and Improves Protection against Pulmonary Mycobacterial Challenge.Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine.In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis.The current status, challenges, and future developments of new tuberculosis vaccines.
P2860
Q26750912-CEC5A530-720A-4BD8-A92E-EFBF82C21256Q26823503-ED148FFC-7497-4E76-AA7D-5A13C8613342Q26862762-A13B46FF-72D1-44CD-B759-D3A1683EBD2AQ27300923-95DE3DC4-A14C-40FB-B94D-9FD92FC20CF2Q27306144-33972A3B-92DF-4028-B627-E4149D3543FDQ28081586-C9BE5642-99E4-447D-8E66-3D3A96CF86E8Q35672595-A809FD1B-016D-42CE-BD24-38A5FBA7751DQ35737990-BBDBF7A0-4A7F-4D4C-8CAF-99614D1929BBQ35998753-F7DC26FB-3115-4B48-AC30-7A7EBD1FE414Q36169358-32B4FE5F-D9D0-4FF7-AF58-B2D80AAE49EDQ36256304-DB4F5BA1-8508-4D09-AF07-0B1DFAD67271Q36264025-C66F5A18-A049-46E9-8881-8D66849C7209Q37433271-22410AE9-8CBC-4790-A8DE-D28B8A7CF314Q38338183-61A1F311-1BD5-4E51-9FA6-65B221BC6642Q38363794-40DC4C71-F3A1-41F0-9613-95287AB971ABQ39045080-69553764-BF38-48E2-8D51-786124548329Q39322060-CDF06E76-729F-4CA6-8383-B8A62811DC3FQ40062766-FEBA848D-8AF9-455A-AB6F-8359702472BBQ40069778-309E9369-23E9-4A69-97CA-187C1CB891E5Q40175400-C3729501-BCAF-4E77-B876-9D5D5E0FE469Q40382721-4BDA326A-46BB-4A6A-ABDC-56DF5961FBD5Q41932554-E8183E32-8C33-4115-BFA1-15C3EFF3F2BDQ43069547-A8C50204-C76D-4664-9C1A-5633D74E91EBQ47553632-B99040CB-B42C-44CC-B6FA-C00D87FD38B3Q48098105-2C3F2725-9FD2-4DB4-8545-7762E7499C05Q52337140-E7565B27-9559-4FD3-8296-1F85B7409468
P2860
Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge.
description
2014 nî lūn-bûn
@nan
2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Aerosol vaccination with AERAS ...... terium tuberculosis challenge.
@ast
Aerosol vaccination with AERAS ...... terium tuberculosis challenge.
@en
type
label
Aerosol vaccination with AERAS ...... terium tuberculosis challenge.
@ast
Aerosol vaccination with AERAS ...... terium tuberculosis challenge.
@en
prefLabel
Aerosol vaccination with AERAS ...... terium tuberculosis challenge.
@ast
Aerosol vaccination with AERAS ...... terium tuberculosis challenge.
@en
P2093
P2860
P356
P1476
Aerosol vaccination with AERAS ...... terium tuberculosis challenge.
@en
P2093
Andrew A Lackner
Chad J Roy
Charles A Scanga
David A Hokey
Deepak Kaushal
Diane L Bolton
Donata R Sizemore
James L Blanchard
Jerald C Sadoff
Mario Roederer
P2860
P304
P356
10.4049/JIMMUNOL.1400676
P407
P577
2014-07-14T00:00:00Z