Origins of the specificity of tissue-type plasminogen activator
about
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8Profiling constitutive proteolytic events in vivoDeterminants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with MesotrypsinStructural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitorsReaction kinetics of protease with substrate phage. Kinetic model developed using stromelysin.Substrate specificity of human collagenase 3 assessed using a phage-displayed peptide library.A unique substrate recognition profile for matrix metalloproteinase-2.Discovery of substrate for type I signal peptidase SpsB from Staphylococcus aureus.Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin.Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate librariesEngineering exosite peptides for complete inhibition of factor VIIa using a protease switch with substrate phage.Substrate specificity of the Escherichia coli outer membrane protease OmpT.Phage display substrate: a blind method for determining protease specificity.Role of P225 and the C136-C201 disulfide bond in tissue plasminogen activator.Structural and energetic determinants of the S1-site specificity in serine proteases.The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin.Structural and kinetic determinants of protease substratesStructural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator.Screening E3 substrates using a live phage display libraryProteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites.Why Ser and not Thr brokers catalysis in the trypsin foldSmall Molecule Active Site Directed Tools for Studying Human CaspasesDistinguishing the specificities of closely related proteases. Role of P3 in substrate and inhibitor discrimination between tissue-type plasminogen activator and urokinase.Novel cross-talk between three cardiovascular regulators: thrombin cleavage fragment of Jagged1 induces fibroblast growth factor 1 expression and releaseA residue in the S2 subsite controls substrate selectivity of matrix metalloproteinase-2 and matrix metalloproteinase-9.Molecular determinants involved in activation of caspase 7Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke.Revisiting catalysis by chymotrypsin family serine proteases using peptide substrates and inhibitors with unnatural main chains.Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.An overview of serine proteases.Localization of epitopes for monoclonal antibodies to urokinase-type plasminogen activator: relationship between epitope localization and effects of antibodies on molecular interactions of the enzyme.Substrate hydrolysis by matrix metalloproteinase-9.Optimal subsite occupancy and design of a selective inhibitor of urokinase.Identification of a hydrophobic exosite on tissue type plasminogen activator that modulates specificity for plasminogen.Variants of tissue-type plasminogen activator that display extraordinary resistance to inhibition by the serpin plasminogen activator inhibitor type 1.Directing sequence-specific proteolysis to new targets. The influence of loop size and target sequence on selective proteolysis by tissue-type plasminogen activator and urokinase-type plasminogen activator.Trimeresurus stejnegeri snake venom plasminogen activator. Site-directed mutagenesis and molecular modeling.
P2860
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P2860
Origins of the specificity of tissue-type plasminogen activator
description
1995 nî lūn-bûn
@nan
1995 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Origins of the specificity of tissue-type plasminogen activator
@ast
Origins of the specificity of tissue-type plasminogen activator
@en
type
label
Origins of the specificity of tissue-type plasminogen activator
@ast
Origins of the specificity of tissue-type plasminogen activator
@en
prefLabel
Origins of the specificity of tissue-type plasminogen activator
@ast
Origins of the specificity of tissue-type plasminogen activator
@en
P2093
P2860
P356
P1476
Origins of the specificity of tissue-type plasminogen activator
@en
P2093
P2860
P304
P356
10.1073/PNAS.92.17.7627
P407
P577
1995-08-01T00:00:00Z