about
Evolution of minimal specificity and promiscuity in steroid hormone receptorsIn the light of directed evolution: pathways of adaptive protein evolutionThe primary diterpene synthase products of Picea abies levopimaradiene/abietadiene synthase (PaLAS) are epimers of a thermally unstable diterpenolStructure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulationExploring protein fitness landscapes by directed evolutionQuantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthasesSystems biology of the structural proteomeAccessing Nature's diversity through metabolic engineering and synthetic biologyDefining the Product Chemical Space of Monoterpenoid SynthasesX-ray Crystal Structure of Aristolochene Synthase from Aspergillus terreus and Evolution of Templates for the Cyclization of Farnesyl Diphosphate † , ‡Rational Conversion of Substrate and Product Specificity in a Salvia Monoterpene Synthase: Structural Insights into the Evolution of Terpene Synthase FunctionExploring biosynthetic diversity with trichodiene synthaseStructural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233-Mg2+B motifDesign of protein function leaps by directed domain interface evolutionStructural Basis for Exquisite Specificity of Affinity Clamps, Synthetic Binding Proteins Generated through Directed Domain-interface EvolutionStructure of Epi-Isozizaene Synthase from Streptomyces coelicolor A3(2), a Platform for New Terpenoid Cyclization Templates ,A site-saturated mutagenesis study of pentaerythritol tetranitrate reductase reveals that residues 181 and 184 influence ligand binding, stereochemistry and reactivityAn Engineered Monolignol 4-O-Methyltransferase Depresses Lignin Biosynthesis and Confers Novel Metabolic Capability in ArabidopsisReprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi -Isozizaene SynthaseRational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiencyDirected divergent evolution of a thermostable D-tagatose epimerase towards improved activity for two hexose substratesSynthetic biology to access and expand nature's chemical diversityRapidly diverging evolution of an atypical alkaline phosphatase (PhoA(aty)) in marine phytoplankton: insights from dinoflagellate alkaline phosphatasesIdentification of a fungal 1,8-cineole synthase from Hypoxylon sp. with specificity determinants in common with the plant synthasesBiochemical and genomic characterization of terpene synthases in Magnolia grandifloraStructural and functional evolution of positively selected sites in pine glutathione S-transferase enzyme familyGeneration of new protein functions by nonhomologous combinations and rearrangements of domains and modules.Molecular signatures-based prediction of enzyme promiscuity.The rise of chemodiversity in plants.Single-shot characterization of enzymatic reaction constants Km and kcat by an acoustic-driven, bubble-based fast micromixer.Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I.Emergence of novel functions in transcriptional regulators by regression to stem protein types.Functional specificity lies within the properties and evolutionary changes of amino acidsNatural variation in monoterpene synthesis in kiwifruit: transcriptional regulation of terpene synthases by NAC and ETHYLENE-INSENSITIVE3-like transcription factors.Gathering computational genomics and proteomics to unravel adaptive evolutionAdvanced biofuel production in microbes.Synthetic biology approaches in drug discovery and pharmaceutical biotechnology.Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control.Redesigning enzymes based on adaptive evolution for optimal function in synthetic metabolic pathwaysMetabolic engineering of sesquiterpene metabolism in yeast.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Designed divergent evolution of enzyme function.
@ast
Designed divergent evolution of enzyme function.
@en
type
label
Designed divergent evolution of enzyme function.
@ast
Designed divergent evolution of enzyme function.
@en
prefLabel
Designed divergent evolution of enzyme function.
@ast
Designed divergent evolution of enzyme function.
@en
P2860
P356
P1433
P1476
Designed divergent evolution of enzyme function.
@en
P2093
Jay D Keasling
Yasuo Yoshikuni
P2860
P2888
P304
P356
10.1038/NATURE04607
P407
P577
2006-02-22T00:00:00Z
P6179
1051333272