A single destabilizing mutation (F9S) promotes concerted unfolding of an entire globular domain in gammaS-crystallin.
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The Human W42R D-Crystallin Mutant Structure Provides a Link between Congenital and Age-related CataractsStructure and Dynamics of the Fish Eye Lens Protein, γM7-CrystallinNuclear Magnetic Resonance Structure of a Major Lens Protein, Human γC-Crystallin: Role of the Dipole Moment in Protein SolubilityThe mutation V42M distorts the compact packing of the human gamma-S-crystallin molecule, resulting in congenital cataractPathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesAn introduction to NMR-based approaches for measuring protein dynamics.The molecular refractive function of lens γ-Crystallins.Characterization of a transient unfolding intermediate in a core mutant of γS-crystallin.Wild-type human γD-crystallin promotes aggregation of its oxidation-mimicking, misfolding-prone W42Q mutant.The βγ-crystallins: native state stability and pathways to aggregation.γ-Crystallins of the chicken lens: remnants of an ancient vertebrate gene family in birds.A role for γS-crystallin in the organization of actin and fiber cell maturation in the mouse lensProtein misfolding and aggregation in cataract disease and prospects for prevention.Solution properties of γ-crystallins: compact structure and low frictional ratio are conserved properties of diverse γ-crystallins.Aggregation of Trp > Glu point mutants of human gamma-D crystallin provides a model for hereditary or UV-induced cataract.Inhibition of unfolding and aggregation of lens protein human gamma D crystallin by sodium citrate.Amyloid β-Sheet Secondary Structure Identified in UV-Induced Cataracts of Porcine Lenses using 2D IR Spectroscopy.
P2860
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P2860
A single destabilizing mutation (F9S) promotes concerted unfolding of an entire globular domain in gammaS-crystallin.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A single destabilizing mutatio ...... r domain in gammaS-crystallin.
@ast
A single destabilizing mutatio ...... r domain in gammaS-crystallin.
@en
type
label
A single destabilizing mutatio ...... r domain in gammaS-crystallin.
@ast
A single destabilizing mutatio ...... r domain in gammaS-crystallin.
@en
prefLabel
A single destabilizing mutatio ...... r domain in gammaS-crystallin.
@ast
A single destabilizing mutatio ...... r domain in gammaS-crystallin.
@en
P2093
P2860
P1476
A single destabilizing mutatio ...... r domain in gammaS-crystallin.
@en
P2093
Blake Jones
Bryon Mahler
Graeme Wistow
Jodie Toward
Keith Wyatt
Lijin Dong
Soojin Lee
Zhengrong Wu
P2860
P304
P356
10.1016/J.JMB.2010.04.003
P407
P577
2010-04-09T00:00:00Z