Strategies for the Design of Drugs Targeting RNA and RNA-Protein Complexes.
about
Arenavirus reverse genetics: new approaches for the investigation of arenavirus biology and development of antiviral strategiesRecognition of the spliceosomal branch site RNA helix on the basis of surface and electrostatic featuresSmall molecules targeting viral RNAConformational inhibition of the hepatitis C virus internal ribosome entry site RNAThe 1.19 A X-ray structure of 2'-O-Me(CGCGCG)(2) duplex shows dehydrated RNA with 2-methyl-2,4-pentanediol in the minor grooveEncapsulating streptomycin within a small 40-mer RNANovel Ligands for a Purine Riboswitch Discovered by RNA-Ligand DockingCharge reduction and thermodynamic stabilization of substrate RNAs inhibit RNA editingPrincipal component and clustering analysis on molecular dynamics data of the ribosomal L11·23S subdomainSelection of RRE RNA binding peptides using a kanamycin antitermination assay.Conformational dynamics of RNA-peptide binding: a molecular dynamics simulation study.Targeting the HIV trans-activation responsive region--approaches towards RNA-binding drugs.SCAN--a high-throughput assay for detecting small molecule binding to RNA targets.1,3-Diazepanes of natural product-like complexity from cyanamide-induced rearrangement of epoxy-delta-lactams.Footprinting, circular dichroism and UV melting studies on neomycin B binding to the packaging region of human immunodeficiency virus type-1 RNA.Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site.Reverse genetics approaches to combat pathogenic arenavirusesRNA-acting antibiotics: in-vitro selection of RNA aptamers for the design of new bioactive molecules less susceptible to bacterial resistance.Using pyrene-labeled HIV-1 TAR to measure RNA-small molecule binding.Applying a high-throughput fluorescence polarization assay for the discovery of chemical probes blocking La:RNA interactions in vitro and in cells.Anti-viral opportunities during transcriptional activation of latent HIV in the host chromatin.Direct observation of aminoglycoside-RNA binding by localized surface plasmon resonance spectroscopy.Mimicking Ribosomal Unfolding of RNA Pseudoknot in a Protein Channel.Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA.Influence of dimethylsulfoxide on RNA structure and ligand binding.A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer.Attenuating HIV Tat/TAR-mediated protein expression by exploring the side chain length of positively charged residues.Analyzing the flexibility of RNA structures by constraint counting.Monitoring aminoglycoside-induced conformational changes in 16S rRNA through acrylamide quenching.The size of the aryl linker between two polyaza-cyclophane moieties controls the binding selectivity to ds-RNA vs. ds-DNA.Novel acyclic deoxystreptamine mimetics targeting the ribosomal decoding site.Synthesis of 2'-aminoalkyl-substituted fluorinated nucleobases and their influence on the kinetic properties of hammerhead ribozymes.Surface plasmon resonance evaluation of various aminoglycoside-RNA hairpin interactions reveals low degree of selectivity.Modelling protein-RNA interactions: an electron density study of the guanidinium and formate complexes with RNA bases.Molecular recognition of nucleic acids: coralyne binds strongly to poly(A).Aminoglycoside-quinacridine conjugates: towards recognition of the P6.1 element of telomerase RNA.Multiple keys for a single lock: the unusual structural plasticity of the nucleotidyltransferase (4')/kanamycin complex.Drugging tRNA aminoacylation.Selective modification of the 3''-amino group of kanamycin prevents significant loss of activity in resistant bacterial strains.Photo-induced uncaging of a specific Re(i) organometallic complex in living cells
P2860
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P2860
Strategies for the Design of Drugs Targeting RNA and RNA-Protein Complexes.
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2000 nî lūn-bûn
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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2000 թվականի հունիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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name
Strategies for the Design of Drugs Targeting RNA and RNA-Protein Complexes.
@ast
Strategies for the Design of Drugs Targeting RNA and RNA-Protein Complexes.
@en
Strategies for the Design of Drugs Targeting RNA and RNA-Protein Complexes.
@nl
type
label
Strategies for the Design of Drugs Targeting RNA and RNA-Protein Complexes.
@ast
Strategies for the Design of Drugs Targeting RNA and RNA-Protein Complexes.
@en
Strategies for the Design of Drugs Targeting RNA and RNA-Protein Complexes.
@nl
prefLabel
Strategies for the Design of Drugs Targeting RNA and RNA-Protein Complexes.
@ast
Strategies for the Design of Drugs Targeting RNA and RNA-Protein Complexes.
@en
Strategies for the Design of Drugs Targeting RNA and RNA-Protein Complexes.
@nl
P1433
P1476
Strategies for the Design of Drugs Targeting RNA and RNA-Protein Complexes.
@en
P2093
P304
P356
10.1002/1521-3773(20000602)39:11<1890::AID-ANIE1890>3.0.CO;2-D
P577
2000-06-01T00:00:00Z