Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling. - Wikidata - wikimedia - TriplyDB

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.

http://www.wikidata.org/entity/Q34002570

about

Diversity-oriented synthetic strategies applied to cancer chemical biology and drug discovery Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes Accelerating glioblastoma drug discovery: Convergence of patient-derived models, genome editing and phenotypic screening New small molecules targeting apoptosis and cell viability in osteosarcoma Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.Transcriptional Characterization of Compounds: Lessons Learned from the Public LINCS Data.Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.The Image Data Resource: A Bioimage Data Integration and Publication Platform.Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects Advances in discovering small molecules to probe protein function in a systems context.The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods.Real-Time Biological Annotation of Synthetic Compounds.Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes.Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives.A dataset of images and morphological profiles of 30,000 small-molecule treatments using the Cell Painting assay.Time series modeling of live-cell shape dynamics for image-based phenotypic profiling.Systematic morphological profiling of human gene and allele function via Cell Painting.Small-molecule phenotypic screening with stem cells.Developing predictive assays: the phenotypic screening "rule of 3".High-Throughput Imaging for the Discovery of Cellular Mechanisms of Disease.Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.High-resolution phenotypic profiling of natural products-induced effects on the single-cell level.Application of a phenotypic drug discovery strategy to identify biological and chemical starting points for inhibition of TSLP production in lung epithelial cells.Repurposing High-Throughput Image Assays Enables Biological Activity Prediction for Drug Discovery.A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.Highlights from the 51st EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2016.A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations.Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation.Machine learning and image-based profiling in drug discovery

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Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.

http://www.wikidata.org/entity/Q34002570

description

2014 nî lūn-bûn

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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2014 թվականի հուլիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Proceedings of the National Academy of Sciences of the United States of America

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Toward performance-diverse sma ...... ed high-dimensional profiling.

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Alykhan F Shamji

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Aravind Subramanian

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Bradley Taylor

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C Suk-Yee Hon

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Ellen Winchester

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George B Grant

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J Anthony Wilson

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Jeremy R Duvall

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Joshua A Bittker

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Katherine L Sokolnicki

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P2860

Functional discovery via a compendium of expression profiles.

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

Multiplex cytological profiling assay to measure diverse cellular states

On Outliers and Activity Cliffs - Why QSAR Often Disappoints

Diversity and Evenness: A Unifying Notation and Its Consequences

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

Extended-connectivity fingerprints

Predicting ligand binding to proteins by affinity fingerprinting.

Exploring chemical space for drug discovery using the chemical universe database.

Chemoproteomics as a basis for post-genomic drug discovery.

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111

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Anne E Carpenter

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264632989

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25024206

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