Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.
about
Diversity-oriented synthetic strategies applied to cancer chemical biology and drug discoveryAdvancing Biological Understanding and Therapeutics Discovery with Small-Molecule ProbesAccelerating glioblastoma drug discovery: Convergence of patient-derived models, genome editing and phenotypic screeningNew small molecules targeting apoptosis and cell viability in osteosarcomaImproving drug discovery with high-content phenotypic screens by systematic selection of reporter cell linesHarnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.Transcriptional Characterization of Compounds: Lessons Learned from the Public LINCS Data.Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.The Image Data Resource: A Bioimage Data Integration and Publication Platform.Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed EffectsAdvances in discovering small molecules to probe protein function in a systems context.The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods.Real-Time Biological Annotation of Synthetic Compounds.Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes.Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives.A dataset of images and morphological profiles of 30,000 small-molecule treatments using the Cell Painting assay.Time series modeling of live-cell shape dynamics for image-based phenotypic profiling.Systematic morphological profiling of human gene and allele function via Cell Painting.Small-molecule phenotypic screening with stem cells.Developing predictive assays: the phenotypic screening "rule of 3".High-Throughput Imaging for the Discovery of Cellular Mechanisms of Disease.Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.High-resolution phenotypic profiling of natural products-induced effects on the single-cell level.Application of a phenotypic drug discovery strategy to identify biological and chemical starting points for inhibition of TSLP production in lung epithelial cells.Repurposing High-Throughput Image Assays Enables Biological Activity Prediction for Drug Discovery.A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.Highlights from the 51st EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2016.A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations.Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation.Machine learning and image-based profiling in drug discovery
P2860
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P2860
Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.
description
2014 nî lūn-bûn
@nan
2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Toward performance-diverse sma ...... ed high-dimensional profiling.
@ast
Toward performance-diverse sma ...... ed high-dimensional profiling.
@en
Toward performance-diverse sma ...... ed high-dimensional profiling.
@nl
type
label
Toward performance-diverse sma ...... ed high-dimensional profiling.
@ast
Toward performance-diverse sma ...... ed high-dimensional profiling.
@en
Toward performance-diverse sma ...... ed high-dimensional profiling.
@nl
prefLabel
Toward performance-diverse sma ...... ed high-dimensional profiling.
@ast
Toward performance-diverse sma ...... ed high-dimensional profiling.
@en
Toward performance-diverse sma ...... ed high-dimensional profiling.
@nl
P2093
P2860
P356
P1476
Toward performance-diverse sma ...... ed high-dimensional profiling.
@en
P2093
Alykhan F Shamji
Aravind Subramanian
Bradley Taylor
C Suk-Yee Hon
Ellen Winchester
George B Grant
J Anthony Wilson
Jeremy R Duvall
Joshua A Bittker
Katherine L Sokolnicki
P2860
P304
10911-10916
P356
10.1073/PNAS.1410933111
P407
P577
2014-07-14T00:00:00Z