The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid. - Wikidata - wikimedia - TriplyDB

The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.

The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.

http://www.wikidata.org/entity/Q34005757

about

Retinoid-xenobiotic interactions: the Ying and the Yang Role of Retinoic Acid-Metabolizing Cytochrome P450s, CYP26, in Inflammation and Cancer Identification of Tazarotenic Acid as the First Xenobiotic Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1 Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling.Retinoids modulate thioacetamide-induced acute hepatotoxicity Therapeutic potential of the inhibition of the retinoic acid hydroxylases CYP26A1 and CYP26B1 by xenobiotics.Multiple cytochrome P-450 genes are concomitantly regulated by vitamin A under steady-state conditions and by retinoic acid during hepatic first-pass metabolism.Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations.Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylase.Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids Drug metabolism by CYP2C8.3 is determined by substrate dependent interactions with cytochrome P450 reductase and cytochrome b5.Pharmacological inhibition of ALDH1A in mice decreases all-trans retinoic acid concentrations in a tissue specific manner Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases Drug-induced Liver Fibrosis: Testing Nevirapine in a Viral-like Liver Setting Using Histopathology, MALDI IMS, and Gene Expression.Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression.Potential for use of retinoic acid as an oral vaccine adjuvant.Stereoselective formation and metabolism of 4-hydroxy-retinoic Acid enantiomers by cytochrome p450 enzymes.Enzymology of retinoic acid biosynthesis and degradation.Cytochrome P450s in the regulation of cellular retinoic acid metabolism Regulation of cyp26a1 on Th17 cells in mouse peri-implantation Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions.Development and Characterization of Novel and Selective Inhibitors of Cytochrome P450 CYP26A1, the Human Liver Retinoic Acid Hydroxylase.Inhibition of the all-trans Retinoic Acid (atRA) Hydroxylases CYP26A1 and CYP26B1 Results in Dynamic, Tissue-Specific Changes in Endogenous atRA Signaling.Accelerated Skeletal Maturation in Disorders of Retinoic Acid Metabolism: A Case Report and Focused Review of the Literature.Direct protein-protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1 Retinoic Acid Synthesis and Degradation.Generating retinoic acid gradients by local degradation during craniofacial development: One cell's cue is another cell's poison.Physiologically Based Pharmacokinetic Model of All-trans-Retinoic Acid with Application to Cancer Populations and Drug Interactions.Comparison of the ligand binding site of CYP2C8 with CYP26A1 and CYP26B1: a structural basis for the identification of new inhibitors of the retinoic acid hydroxylases.All-trans retinoic acid attenuates the renal interstitial fibrosis lesion in rats but not by transforming growth factor-β1/Smad3 signaling pathway.CYP26C1 Is a Hydroxylase of Multiple Active Retinoids and Interacts with Cellular Retinoic Acid Binding Proteins

P2860

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P2860

The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.

http://www.wikidata.org/entity/Q34005757

description

2010 nî lūn-bûn

@nan

2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.

@ast

The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.

@en

The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.

@nl

type

label

The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.

@ast

The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.

@en

The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.

@nl

prefLabel

The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.

@ast

The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.

@en

The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.

@nl

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J.BCP.2010.05.023

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Biochemical Pharmacology

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The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.

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Alex Zelter

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Jayne E Thatcher

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Nina Isoherranen

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P2860

Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism

A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid

Retinoic acid synthesis and signaling during early organogenesis

The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system

Overview of retinoid metabolism and function

Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites

Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation

Immunoquantitation of FMO1 in human liver, kidney, and intestine

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

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903-912

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10.1016/J.BCP.2010.05.023

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