D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis - Wikidata - wikimedia - TriplyDB

D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

http://www.wikidata.org/entity/Q34006224

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Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?The role of D-serine and glycine as co-agonists of NMDA receptors in motor neuron degeneration and amyotrophic lateral sclerosis (ALS)Neuropathogenesis of HIV-1-associated neurocognitive disorders: a possible involvement of D-serine Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice.Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.Inflammation in ALS and SMA: sorting out the good from the evil.Activity of D-amino acid oxidase is widespread in the human central nervous system.Heterogeneity of D-Serine Distribution in the Human Central Nervous System.Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase The role of D-amino acids in amyotrophic lateral sclerosis pathogenesis: a review.Increased sensitivity to inflammatory pain induced by subcutaneous formalin injection in serine racemase knock-out mice.Roles of quaternary structure and cysteine residues in the activity of human serine racemase.Role of zinc ion for catalytic activity in d-serine dehydratase from Saccharomyces cerevisiae.Identification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis.Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.D-amino acid oxidase controls motoneuron degeneration through D-serine.Blockade of the N-Methyl-D-Aspartate Glutamate Receptor Ameliorates Lipopolysaccharide-Induced Renal Insufficiency.Cross-linking of serine racemase dimer by reactive oxygen species and reactive nitrogen species.Spatiotemporal localization of D-amino acid oxidase and D-aspartate oxidases during development in Caenorhabditis elegans Addressing the Conformational Flexibility of Serine Racemase by Combining Targeted Molecular Dynamics, Conformational Sampling and Docking Studies.Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.Neuron-astrocyte interactions in neurodegenerative diseases: Role of neuroinflammation D-Serine Production, Degradation, and Transport in ALS: Critical Role of Methodology Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis.D-serine as a gliotransmitter and its roles in brain development and disease.D-amino acids in the brain: structure and function of pyridoxal phosphate-dependent amino acid racemases.Development and validation of a sensitive LC-MS/MS method for the determination of D-serine in human plasma.Overdose of D-serine Induces Movement Disorder and Neuromuscular Changes of Zebrafish Larvae.Characterization of chiral amino acids from different milk origins using ultra-performance liquid chromatography coupled to ion-mobility mass spectrometry.D-Amino acids in the brain and mutant rodents lacking D-amino-acid oxidase activity.Protein interacting with C kinase and neurological disorders.The multifaceted role of glial cells in amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis: an update on recent genetic insights.Compromised MAPK signaling in human diseases: an update.Astrocytes in neurodegenerative disease.Taurine Protects Glutamate Neurotoxicity in Motor Neuron Cells.Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility.Novel therapies in development that inhibit motor neuron hyperexcitability in amyotrophic lateral sclerosis.

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P2860

D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

http://www.wikidata.org/entity/Q34006224

description

2007 nî lūn-bûn

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2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2007 թվականի օգոստոսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

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D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

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D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

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D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

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D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

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D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

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D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

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D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

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D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

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SJ.EMBOJ.7601840

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The EMBO Journal

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D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

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Ikuo Nishimoto

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Jumpei Sasabe

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Koichi Okamoto

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Marina Yamada

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Masaaki Matsuoka

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Sadakazu Aiso

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Tomohiro Chiba

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P2860

Human serine racemase: moleular cloning, genomic organization and functional analysis

Differential effect of ik3-1/cables on p53- and p73-induced cell death

Induction of serine racemase by inflammatory stimuli is dependent on AP-1

Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis

Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia

Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine

A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta

Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: a reappraisal using a new HPLC method with coulometric detection in a large cohort of patients

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10.1038/SJ.EMBOJ.7601840

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18

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17762863

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amyotrophic lateral sclerosis

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