Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
about
Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cellsPlk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cellsPlk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progressionPolo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbodyThe crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complexSilencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cellsMolecular dynamics of PLK1 during mitosisMLL5 maintains spindle bipolarity by preventing aberrant cytosolic aggregation of PLK1Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localizationStructural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1Serendipitous alkylation of a Plk1 ligand uncovers a new binding channelStructural basis for the inhibition of Polo-like kinase 1The PLK4-STIL-SAS-6 module at the core of centriole duplicationPolo-like kinase and its inhibitors: Ready for the match to start?Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entryIdentification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assayUse of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis.Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis.PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase.Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation.The NIMA-family kinase, Nek1 affects the stability of centrosomes and ciliogenesis.Over expression of Plk1 does not induce cell division in rat cardiac myocytes in vitro.Multiplexed random peptide library and phospho-specific antibodies facilitate human polo-like kinase 1 inhibitor screenThe natural product Aristolactam AIIIa as a new ligand targeting the polo-box domain of polo-like kinase 1 potently inhibits cancer cell proliferation.Mechanisms underlying Plk1 polo-box domain-mediated biological processes and their physiological significance.Purification and proteomic identification of putative upstream regulators of polo-like kinase-1 from mitotic cell extracts.Coordinate regulation of the mother centriole component nlp by nek2 and plk1 protein kinases.Polo-box domain: a versatile mediator of polo-like kinase function.Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs.The structural basis of localizing polo-like kinase to the flagellum attachment zone in Trypanosoma brucei.Polo-like kinase-activating kinases: Aurora A, Aurora B and what else?Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase.Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancerIdentification of potential Plk1 targets in a cell-cycle specific proteome through structural dynamics of kinase and Polo box-mediated interactionsFeed-forward mechanism of converting biochemical cooperativity to mitotic processes at the kinetochore plateMammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochoresIllumination of mitotic orchestra during cell division: a Polo view
P2860
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P2860
Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
@ast
Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
@en
Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
@nl
type
label
Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
@ast
Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
@en
Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
@nl
prefLabel
Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
@ast
Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
@en
Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
@nl
P2093
P2860
P356
P1476
Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
@en
P2093
Raymond L Erikson
Young-Joo Jang
P2860
P304
P356
10.1073/PNAS.042689299
P407
P50
P577
2002-02-01T00:00:00Z