Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy. - Wikidata - wikimedia - TriplyDB

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.

http://www.wikidata.org/entity/Q34015864

about

Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease p62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stress The ubiquitin-proteasome system and cardiovascular disease Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart The ubiquitin-proteasome system and nonsense-mediated mRNA decay in hypertrophic cardiomyopathy Proteotoxicity: an underappreciated pathology in cardiac disease Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy.The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective.Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltaPKC during reperfusion.Differential protein acetylation assists import of excess SOD2 into mitochondria and mediates SOD2 aggregation associated with cardiac hypertrophy in the murine SOD2-tg heart.Manipulation of death pathways in desmin-related cardiomyopathy Proteomic profiling of endothelin-1-stimulated hypertrophic cardiomyocytes reveals the increase of four different desmin species and alpha-B-crystallin.Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy.Evaluating age-associated phenotypes in a mouse model of protein dyshomeostasis.A knock-in mouse model for the R120G mutation of αB-crystallin recapitulates human hereditary myopathy and cataracts.Increases in the risk of cognitive impairment and alterations of cerebral β-amyloid metabolism in mouse model of heart failure Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target Autophagy and p62 in cardiac proteinopathy.Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes.Dysfunction of the CNS-heart axis in mouse models of Huntington's disease.Changes in the expression of the Alzheimer’s disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction Desmin-related cardiomyopathy: an unfolding story Proteasome functional insufficiency in cardiac pathogenesis.Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy.AbetaPP-overexpression and proteasome inhibition increase alphaB-crystallin in cultured human muscle: relevance to inclusion-body myositis.COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity.CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control Phenotype of cardiomyopathy in cardiac-specific heat shock protein B8 K141N transgenic mouse.Hsp27 (HspB1) and alphaB-crystallin (HspB5) as therapeutic targets.Protein quality control and degradation in cardiomyocytes.Do amyloid oligomers act as traps for misfolded proteins? A hypothesis CHIP protects against cardiac pressure overload through regulation of AMPK.p62 expression and autophagy in αB-crystallin R120G mutant knock-in mouse model of hereditary cataract.Molecular chaperones as regulators of cell death.An endogenously produced fragment of cardiac myosin-binding protein C is pathogenic and can lead to heart failure Intermediate filament diseases: desminopathy.Desmin modifications associate with amyloid-like oligomers deposition in heart failure.The role of the proteasome in heart disease Proteotoxicity and cardiac dysfunction.

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Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.

http://www.wikidata.org/entity/Q34015864

description

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2005年論文

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name

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.

@ast

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.

@en

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.

@nl

type

label

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.

@ast

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.

@en

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.

@nl

prefLabel

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.

@ast

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.

@en

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.

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Proceedings of the National Academy of Sciences of the United States of America

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Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.

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Atsushi Sanbe

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Charles G Glabe

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Chet Villa

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Hanna Osinska

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James Gulick

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Jeffrey Robbins

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Raisa Klevitsky

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Rakez Kayed

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P2860

A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy

A simplified system for generating recombinant adenoviruses

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

Protein aggregation and neurodegenerative disease

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

Aggresomes, inclusion bodies and protein aggregation

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

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