Aminoacyl-tRNA synthesis and translational quality control.
about
Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizuresRecent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetasesCodon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responsesMechanistic insights into cognate substrate discrimination during proofreading in translationThe Mechanism of Pre-transfer Editing in Yeast Mitochondrial Threonyl-tRNA SynthetasePeripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetaseYeast mitochondrial threonyl-tRNA synthetase recognizes tRNA isoacceptors by distinct mechanisms and promotes CUN codon reassignmentStructure and function of a serine carboxypeptidase adapted for degradation of the protein synthesis antibiotic microcin C7Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetaseAncient translation factor is essential for tRNA-dependent cysteine biosynthesis in methanogenic archaeaBiochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug targetStructural phylogenomics retrodicts the origin of the genetic code and uncovers the evolutionary impact of protein flexibilityTrp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signalingIdentification of lethal mutations in yeast threonyl-tRNA synthetase revealing critical residues in its human homolog.Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening.Computational analysis of tRNA identity.Double-sieving-defective aminoacyl-tRNA synthetase causes protein mistranslation and affects cellular physiology and developmentDo anticodons of misacylated tRNAs preferentially mismatch codons coding for the misloaded amino acid?Predicting the pathway involved in post-translational modification of elongation factor P in a subset of bacterial species.tRNA-dependent pre-transfer editing by prokaryotic leucyl-tRNA synthetase.Cell-specific differences in the requirements for translation quality controlSevere oxidative stress induces protein mistranslation through impairment of an aminoacyl-tRNA synthetase editing site.Reduced amino acid specificity of mammalian tyrosyl-tRNA synthetase is associated with elevated mistranslation of Tyr codons.Genomes by design.Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain.Adaptive translation as a mechanism of stress response and adaptation.Identification of the determinants of tRNA function and susceptibility to rapid tRNA decay by high-throughput in vivo analysis.Aminoacyl transfer rate dictates choice of editing pathway in threonyl-tRNA synthetase.Partitioning of tRNA-dependent editing between pre- and post-transfer pathways in class I aminoacyl-tRNA synthetases.Exploring the substrate range of wild-type aminoacyl-tRNA synthetases.Is mitochondrial tRNA(phe) variant m.593T>C a synergistically pathogenic mutation in Chinese LHON families with m.11778G>A?A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activityProofreading in translation: dynamics of the double-sieve modelReprogramming the genetic code.Amino-acid-dependent shift in tRNA synthetase editing mechanisms.Relaxed substrate specificity leads to extensive tRNA mischarging by Streptococcus pneumoniae class I and class II aminoacyl-tRNA synthetasesIn vivo identification of essential nucleotides in tRNALeu to its functions by using a constructed yeast tRNALeu knockout strain.Protein aggregation caused by aminoglycoside action is prevented by a hydrogen peroxide scavenger.New functions of aminoacyl-tRNA synthetases beyond translation.Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy.
P2860
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P2860
Aminoacyl-tRNA synthesis and translational quality control.
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Aminoacyl-tRNA synthesis and translational quality control.
@ast
Aminoacyl-tRNA synthesis and translational quality control.
@en
Aminoacyl-tRNA synthesis and translational quality control.
@nl
type
label
Aminoacyl-tRNA synthesis and translational quality control.
@ast
Aminoacyl-tRNA synthesis and translational quality control.
@en
Aminoacyl-tRNA synthesis and translational quality control.
@nl
prefLabel
Aminoacyl-tRNA synthesis and translational quality control.
@ast
Aminoacyl-tRNA synthesis and translational quality control.
@en
Aminoacyl-tRNA synthesis and translational quality control.
@nl
P1476
Aminoacyl-tRNA synthesis and translational quality control.
@en
P2093
Michael Ibba
Noah Reynolds
P356
10.1146/ANNUREV.MICRO.091208.073210
P50
P577
2009-01-01T00:00:00Z