Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease.
about
Dual subcellular localization in the endoplasmic reticulum and peroxisomes and a vital role in protecting against oxidative stress of fatty aldehyde dehydrogenase are achieved by alternative splicingALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cellsNon-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamilyAldehyde dehydrogenase 1A1 in stem cells and cancerAldehyde dehydrogenases in cellular responses to oxidative/electrophilic stressDiscovery of a Novel Class of Covalent Inhibitor for Aldehyde DehydrogenasesActivation of Human Salivary Aldehyde Dehydrogenase by Sulforaphane: Mechanism and SignificanceSignificant association between decreased ALDH2 activity and increased sensitivity to genotoxic effects in workers occupationally exposed to styreneThe evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination.Over-expression of aldehyde dehydrogenase-2 protects against H₂O₂-induced oxidative damage and apoptosis in peripheral blood mononuclear cells.Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzymeDrug focus: Pharmacogenetic studies related to cyclophosphamide-based therapy.The role of serotonin and possible interaction of serotonin-related genes with alcohol dehydrogenase and aldehyde dehydrogenase genes in alcohol dependence-a reviewAldehyde dehydrogenases: from eye crystallins to metabolic disease and cancer stem cells3-Hydroxyisobutyrate aciduria and mutations in the ALDH6A1 gene coding for methylmalonate semialdehyde dehydrogenase.Analysis of lead toxicity in human cellsCorneal aldehyde dehydrogenases: multiple functions and novel nuclear localizationInteraction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1.Murine pharmacogenomics: using the mouse to understand the genetics of drug therapy.Human aldehyde dehydrogenases: potential pathological, pharmacological, and toxicological impact.Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo.Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors.Identification of 4-Trimethylaminobutyraldehyde Dehydrogenase (TMABA-DH) as a Candidate Serum Autoantibody Target for Kawasaki Disease.Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesisGenetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism.Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism.Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclatureEvaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populations.Association of the ALDH1A1*2 promoter polymorphism with alcohol phenotypes in young adults with or without ALDH2*2.Metabolism and transport of oxazaphosphorines and the clinical implications.Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health.Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family.The role of genetic variability in drug metabolism pathways in breast cancer prognosis.The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes.The role of human aldehyde dehydrogenase in normal and cancer stem cells.Aldehyde dehydrogenase 1 (ALDH1) isoform expression and potential clinical implications in hepatocellular carcinoma.The aldehyde dehydrogenase enzyme 7A1 is functionally involved in prostate cancer bone metastasis.The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistanceN,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes.Fatty aldehyde dehydrogenase multigene family involved in the assimilation of n-alkanes in Yarrowia lipolytica.
P2860
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P2860
Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease.
description
2000 nî lūn-bûn
@nan
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Polymorphisms of human aldehyd ...... r drug metabolism and disease.
@ast
Polymorphisms of human aldehyd ...... r drug metabolism and disease.
@en
Polymorphisms of human aldehyd ...... r drug metabolism and disease.
@nl
type
label
Polymorphisms of human aldehyd ...... r drug metabolism and disease.
@ast
Polymorphisms of human aldehyd ...... r drug metabolism and disease.
@en
Polymorphisms of human aldehyd ...... r drug metabolism and disease.
@nl
prefLabel
Polymorphisms of human aldehyd ...... r drug metabolism and disease.
@ast
Polymorphisms of human aldehyd ...... r drug metabolism and disease.
@en
Polymorphisms of human aldehyd ...... r drug metabolism and disease.
@nl
P356
P1433
P1476
Polymorphisms of human aldehyd ...... r drug metabolism and disease.
@en
P2093
P304
P356
10.1159/000028400
P577
2000-09-01T00:00:00Z