Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control - Wikidata - wikimedia - TriplyDB

Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control

Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control

http://www.wikidata.org/entity/Q34023014

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Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy Phagocyte responses to protozoan infection and how Toxoplasma gondii meets the challenge The gut mucosal immune response to Toxoplasma gondii Nucleotide-oligomerization-domain-2 affects commensal gut microbiota composition and intracerebral immunopathology in acute Toxoplasma gondii induced murine ileitis MAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in mice Chitinase dependent control of protozoan cyst burden in the brain TH1/TH2 paradigm extended: macrophage polarization as an unappreciated pathogen-driven escape mechanism?Secreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis?Long-Term Relationships: the Complicated Interplay between the Host and the Developmental Stages of Toxoplasma gondii during Acute and Chronic Infections Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection Toxoplasma gondii inhibits mast cell degranulation by suppressing phospholipase Cγ-mediated Ca(2+) mobilization.Toxoplasma gondii virulence factor ROP18 inhibits the host NF-κB pathway by promoting p65 degradation.GRA25 is a novel virulence factor of Toxoplasma gondii and influences the host immune response Comparative studies of macrophage-biased responses in mice to infection with Toxoplasma gondii ToxoDB #9 strains of different virulence isolated from China.Co-existence of classical and alternative activation programs in macrophages responding to Toxoplasma gondii The impact of Toll-like-receptor-9 on intestinal microbiota composition and extra-intestinal sequelae in experimental Toxoplasma gondii induced ileitis.New molecular tools in Neospora caninum for studying apicomplexan parasite proteins.Modulation of innate immunity by Toxoplasma gondii virulence effectors.Toxoplasma gondii development of its replicative niche: in its host cell and beyond.Deficiency of a Niemann-Pick, type C1-related protein in toxoplasma is associated with multiple lipidoses and increased pathogenicity.Dual transcriptional profiling of mice and Toxoplasma gondii during acute and chronic infection Partial protective effect of intranasal immunization with recombinant Toxoplasma gondii rhoptry protein 17 against toxoplasmosis in mice Type II Toxoplasma gondii induction of CD40 on infected macrophages enhances interleukin-12 responses Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis Subversion of host cellular functions by the apicomplexan parasites.Seroprevalence and risk factors of Toxoplasma gondii infection in sheep and goats slaughtered for human consumption in Central Ethiopia.Hammondia hammondi harbors functional orthologs of the host-modulating effectors GRA15 and ROP16 but is distinguished from Toxoplasma gondii by a unique transcriptional profile.Toxoplasma gondii triggers phosphorylation and nuclear translocation of dendritic cell STAT1 while simultaneously blocking IFNγ-induced STAT1 transcriptional activity Have it your way: how polymorphic, injected kinases and pseudokinases enable Toxoplasma to subvert host defenses.Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infection Structural and evolutionary adaptation of rhoptry kinases and pseudokinases, a family of coccidian virulence factors CXCR3-dependent CD4⁺ T cells are required to activate inflammatory monocytes for defense against intestinal infection.Toxoplasma gondii prevalent in China induce weaker apoptosis of neural stem cells C17.2 via endoplasmic reticulum stress (ERS) signaling pathways.Forward genetics screens using macrophages to identify Toxoplasma gondii genes important for resistance to IFN-γ-dependent cell autonomous immunity siRNA Screening Identifies the Host Hexokinase 2 (HK2) Gene as an Important Hypoxia-Inducible Transcription Factor 1 (HIF-1) Target Gene in Toxoplasma gondii-Infected Cells Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection.Discovery of a novel Toxoplasma gondii conoid-associated protein important for parasite resistance to reactive nitrogen intermediates.Parasite Manipulation of the Invariant Chain and the Peptide Editor H2-DM Affects Major Histocompatibility Complex Class II Antigen Presentation during Toxoplasma gondii Infection.Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling.K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells.

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Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control

http://www.wikidata.org/entity/Q34023014

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2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Toxoplasma gondii rhoptry kina ...... ase-1-dependent growth control

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Toxoplasma gondii rhoptry kina ...... ase-1-dependent growth control

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Toxoplasma gondii rhoptry kina ...... ase-1-dependent growth control

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Toxoplasma gondii rhoptry kina ...... ase-1-dependent growth control

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Toxoplasma gondii rhoptry kina ...... ase-1-dependent growth control

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Toxoplasma gondii rhoptry kina ...... ase-1-dependent growth control

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Toxoplasma gondii rhoptry kina ...... ase-1-dependent growth control

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Toxoplasma gondii rhoptry kina ...... ase-1-dependent growth control

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Toxoplasma gondii rhoptry kina ...... ase-1-dependent growth control

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Toxoplasma gondii rhoptry kina ...... ase-1-dependent growth control

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Barbara A Butcher

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Barbara A Fox

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David J Bzik

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De'Broski R Herbert

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Eric Y Denkers

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Kirk J Maurer

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Leah M Rommereim

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Sung Guk Kim

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P2860

Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis

Dynamics of neutrophil migration in lymph nodes during infection.

Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production.

Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis

A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.

Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection.

Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.

Nitric oxide: a cytotoxic activated macrophage effector molecule.

TLR11 activation of dendritic cells by a protozoan profilin-like protein.

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e1002236

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scholarly article

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10.1371/JOURNAL.PPAT.1002236

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9

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Felix Yarovinsky

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2011-09-08T00:00:00Z

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51652849

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Toxoplasma gondii

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3169547

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