Sialylation is essential for early development in mice. - Wikidata - wikimedia - TriplyDB

Sialylation is essential for early development in mice.

Sialylation is essential for early development in mice.

http://www.wikidata.org/entity/Q34024283

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The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis Diversity of microbial sialic acid metabolism Colloquium paper: uniquely human evolution of sialic acid genetics and biology Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration GNE is involved in the early development of skeletal and cardiac muscle Crystal Structure of the N-Acetylmannosamine Kinase Domain of GNE GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism Hereditary inclusion body myopathy: a decade of progress Non-specific accumulation of glycosphingolipids in GNE myopathy Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine Domain-specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase Metabolic manipulation of glycosylation disorders in humans and animal models Preclinical assessment of wt GNE gene plasmid for management of hereditary inclusion body myopathy 2 (HIBM2)N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution Intravenous immune globulin in hereditary inclusion body myopathy: a pilot study Cell surface sialylation and fucosylation are regulated by L1 via phospholipase Cgamma and cooperate to modulate neurite outgrowth, cell survival and migration.Insights into the evolution of sialic acid catabolism among bacteria.Sialic acid utilisation and synthesis in the neonatal rat revisited Ganglioside GM3 levels are altered in a mouse model of HIBM: GM3 as a cellular marker of the disease.Molecular modeling of the bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase and predictions of structural effects of mutations associated with HIBM and sialuria.Effects of altered sialic acid biosynthesis on N-linked glycan branching and cell surface interactions N-acetyl-D-mannosamine treatment alleviates age-related decline in place-learning ability in dogs Molecular diagnosis of hereditary inclusion body myopathy by linkage analysis and identification of a novel splice site mutation in GNE.An oncogenic protein Golgi phosphoprotein 3 up-regulates cell migration via sialylation.Structure, biological functions and applications of the AB5 toxins.Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice.Sialylation of Thomsen-Friedenreich antigen is a noninvasive blood-based biomarker for GNE myopathy.UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): A Master Regulator of Sialic Acid Synthesis.Perspectives on distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy: contributions from an animal model. Lack of sialic acid, a central determinant in sugar chains, causes myopathy?Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis ST3GAL3 mutations impair the development of higher cognitive functions.Mutation update for GNE gene variants associated with GNE myopathy.A proteome signature for intrauterine growth restriction derived from multifactorial analysis of mass spectrometry-based cord blood serum profiling.Evidences for the involvement of cell surface glycans in stem cell pluripotency and differentiation.A preclinical trial of sialic acid metabolites on distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy, a sugar-deficient myopathy: a review.A novel missense mutation in the GNE gene in an Iranian patient with hereditary inclusion body myopathy.The CMP-sialic acid transporter is localized in the medial-trans Golgi and possesses two specific endoplasmic reticulum export motifs in its carboxyl-terminal cytoplasmic tail.Atypical presentation of GNE myopathy with asymmetric hand weakness.Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases.Transcript analysis of stem cells

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Sialylation is essential for early development in mice.

http://www.wikidata.org/entity/Q34024283

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2002 nî lūn-bûn

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2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2002 թվականի ապրիլին հրատարակված գիտական հոդված

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2002年の論文

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2002年论文

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Sialylation is essential for early development in mice.

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Sialylation is essential for early development in mice.

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Sialylation is essential for early development in mice.

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type

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Sialylation is essential for early development in mice.

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Sialylation is essential for early development in mice.

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Sialylation is essential for early development in mice.

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Sialylation is essential for early development in mice.

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Sialylation is essential for early development in mice.

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Sialylation is essential for early development in mice.

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Proceedings of the National Academy of Sciences of the United States of America

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Sialylation is essential for early development in mice.

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P2093

Elvira Rohde

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Ivan Horak

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Klaus-Peter Knobeloch

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Lothar Lucka

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Martina Schwarzkopf

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Nicola Wiechens

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Rüdiger Horstkorte

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Stephan Hinderlich

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Werner Reutter

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P2860

UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation

A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase

Mutations in the human UDP-N-acetylglucosamine 2-epimerase gene define the disease sialuria and the allosteric site of the enzyme

Establishment in culture of pluripotential cells from mouse embryos

Primary structure and expression analysis of human UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase, the bifunctional enzyme in neuraminic acid biosynthesis

The UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase gene is mutated in recessive hereditary inclusion body myopathy

A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Purification and characterization of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Sialuria: a second case

Tissue expression and amino acid sequence of murine UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase

Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates

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5267-5270

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scholarly article

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10.1073/PNAS.072066199

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8

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99

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2002-04-02T00:00:00Z

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11929971

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