Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing γδ T cells
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Recent Advances in Kawasaki DiseaseClose link between development and function of gamma-delta T cellsGenetic requirements for the development and differentiation of interleukin-17-producing γδ T cellsC-Src and c-Yes are two unlikely partners of spermatogenesis and their roles in blood-testis barrier dynamics.γδ T cells acquire effector fates in the thymus and differentiate into cytokine-producing effectors in a Listeria model of infection independently of CD28 costimulation.Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice.Concordance of increased B1 cell subset and lupus phenotypes in mice and humans is dependent on BLK expression levels.Dysfunctional BLK in common variable immunodeficiency perturbs B-cell proliferation and ability to elicit antigen-specific CD4+ T-cell help.Ectopic expression of a novel CD22 splice-variant regulates survival and proliferation in malignant T cells from cutaneous T cell lymphoma (CTCL) patients.The autoimmunity-associated BLK haplotype exhibits cis-regulatory effects on mRNA and protein expression that are prominently observed in B cells early in development.Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets.Innate-like functions of natural killer T cell subsets result from highly divergent gene programsCD19+ B cell subsets in the peripheral blood and skin lesions of psoriasis patients and their correlations with disease severityDistinct gene expression patterns correlate with developmental and functional traits of iNKT subsets.Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription.Unraveling the genetic component of systemic sclerosis.The natural and the inducible: interleukin (IL)-17-producing γδ T cells.Functional development of γδ T cells.Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets.Pharmacology of Src family kinases and therapeutic implications of their modulators.The Jekyll and Hyde story of IL17-Producing γδT Cells.A network of high-mobility group box transcription factors programs innate interleukin-17 production.Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypesIL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vγ6(+)γδ T cellsIL-17+ γδ T cells as kick-starters of inflammation.Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells.HEB is required for the specification of fetal IL-17-producing γδ T cells.γδTCR recruits the Syk/PI3K axis to drive proinflammatory differentiation program.Thymic Program Directing the Functional Development of γδT17 Cells.
P2860
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P2860
Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing γδ T cells
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Unexpected role for the B cell ...... of IL-17-producing γδ T cells
@ast
Unexpected role for the B cell ...... of IL-17-producing γδ T cells
@en
Unexpected role for the B cell ...... of IL-17-producing γδ T cells
@nl
type
label
Unexpected role for the B cell ...... of IL-17-producing γδ T cells
@ast
Unexpected role for the B cell ...... of IL-17-producing γδ T cells
@en
Unexpected role for the B cell ...... of IL-17-producing γδ T cells
@nl
prefLabel
Unexpected role for the B cell ...... of IL-17-producing γδ T cells
@ast
Unexpected role for the B cell ...... of IL-17-producing γδ T cells
@en
Unexpected role for the B cell ...... of IL-17-producing γδ T cells
@nl
P2093
P2860
P356
P1476
Unexpected role for the B cell ...... of IL-17-producing γδ T cells
@en
P2093
Karen Laky
Renee M Laird
Sandra M Hayes
P2860
P304
P356
10.4049/JIMMUNOL.1002766
P407
P577
2010-10-25T00:00:00Z