Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels - Wikidata - wikimedia - TriplyDB

Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels

Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels

http://www.wikidata.org/entity/Q34028692

about

PI3K: An Attractive Candidate for the Central Integration of Metabolism and Reproduction Leptin signaling and leptin resistance Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance Developmental specification of metabolic circuitry Obesity Increases Mortality and Modulates the Lung Metabolome during Pandemic H1N1 Influenza Virus Infection in Mice.Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period.Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala.Melanocortin-3 receptors expressed in Nkx2.1(+ve) neurons are sufficient for controlling appetitive responses to hypocaloric conditioning Neurobiology of food intake in health and disease.Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system.Intestinal deletion of leptin signaling alters activity of nutrient transporters and delayed the onset of obesity in mice.20 years of leptin: connecting leptin signaling to biological function New pharmacological perspectives for the leptin receptor in the treatment of obesity Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells.Distinct networks of leptin- and insulin-sensing neurons regulate thermogenic responses to nutritional and cold challenges.Neuroanatomy of body weight control: lessons learned from leptin.Central insulin signaling modulates hypothalamus-pituitary-adrenal axis responsiveness Maternal obesity caused by overnutrition exposure leads to reversal learning deficits and striatal disturbance in rats.Intracellular leptin-signaling pathways in hypothalamic neurons: the emerging role of phosphatidylinositol-3 kinase-phosphodiesterase-3B-cAMP pathway TRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neurons Challenges and opportunities of defining clinical leptin resistance Persistent expression of activated notch in the developing hypothalamus affects survival of pituitary progenitors and alters pituitary structure.Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals.Embryonic birthdate of hypothalamic leptin-activated neurons in mice.Ablation of intact hypothalamic and/or hindbrain TrkB signaling leads to perturbations in energy balance.Minireview: CNS Mechanisms of Leptin Action.Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance Reducing Adiposity in a Critical Developmental Window Has Lasting Benefits in Mice.Dose-dependent effects of a genistein-enriched diet in the heart of ovariectomized mice.Notch/Rbpjκ signaling regulates progenitor maintenance and differentiation of hypothalamic arcuate neurons Effects of metformin in children and adolescents with Prader-Willi syndrome and early-onset morbid obesity: a pilot study.Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor.Preserved energy balance in mice lacking FoxO1 in neurons of Nkx2.1 lineage reveals functional heterogeneity of FoxO1 signaling within the hypothalamus.Light and chemical control of neuronal circuits: possible applications in neurotherapy.Structure, production and signaling of leptin.Overexpression of gastric leptin precedes adipocyte leptin during high-fat diet and is linked to 5HT-containing enterochromaffin cells.Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance.Toward a Wiring Diagram Understanding of Appetite Control.A role for leptin-regulated neurocircuitry in subordination stress.Leptin does not directly affect CNS serotonin neurons to influence appetite.

P2860

Q21131282-0F53A022-B431-4D97-B185-FCC04BD3F287 Q26865174-D0BFC720-F296-41CB-907D-100154064CFE Q28508697-7842E401-DBF0-4E56-A628-C8A624ED4AD8 Q30373177-CDB3F863-77F6-4A6D-869D-345536009CBB Q30373574-50CD84B3-F220-4679-ACF5-B0DC5B152A73 Q30405254-75592D42-2C8E-48F5-8E08-95A480FEDE3A Q30463978-F981E4DB-D3AC-49A0-8A80-EB5DF8C04236 Q30842018-1E758C0E-2C3D-4B1D-AFC4-08D9C3B83A52 Q33825213-8B1FAE48-0175-44F4-BDD0-662DA12E2D3E Q34014371-7983BEFC-83CE-489E-A68A-59DA20BFC624 Q34072619-45C4ACAF-A813-48AB-8000-E8C1CC84BC02 Q34221428-9F0CD62C-B1EC-4FDC-98E4-C943BD64D6DD Q34330557-ACDD324F-73A5-465C-B11A-D05E9B0F31D5 Q34590231-98C86E6B-01D3-42C4-81F6-933F6FEBE6B4 Q34762518-A7945F82-4506-493D-9392-6B6759D06A96 Q35015819-DEA9A939-5821-4060-8E0C-26658D148E38 Q35040573-C71D1AA5-6F66-47DF-8929-1423633CE2F3 Q35041082-F7736CD1-917A-4B7E-83B0-FCF82F044CC8 Q35088709-96625E08-5AF8-4B24-9116-404463443A64 Q35163093-70C7E346-E65B-4CC7-8CDE-F9399E4C5BAC Q35762785-82AA8759-996F-4CB2-9E09-10F8E01D832E Q35904479-D52D45DF-FE86-40BD-9963-08C45741A4FF Q35943952-4D2DC3C9-C0F8-4CD7-8653-69FA4AC56185 Q36114036-125AD0CF-BC98-4796-B324-4F5B0C6660C9 Q36246015-3F1F15CA-FFBF-45A6-BAD0-24693F98BA3F Q36415790-06F0A4E4-083B-463D-B370-E2921366211A Q36493391-E5C2522A-EEAE-419C-9344-2ECE14BB0B5F Q36521172-5DA56F90-46B6-48AB-B684-27E687E60E85 Q36947507-BEA066BD-16D7-46EB-8D59-643CC09EEC77 Q37091639-99C5E8CA-1933-44A0-85C6-3121171A440A Q37394811-547D6628-D874-4C55-B114-CBBB6729553B Q37702651-A3016EF1-36A0-4214-92D1-2BCC2D1FD14C Q37715594-AD38C62B-B54D-4343-AAFD-8D8B6F1B9153 Q38239172-D9198197-76F1-4272-86E4-BF5B721662B1 Q38259090-2ED26733-1BF8-4C74-ABAF-AAE3B80B92AA Q38309409-2ED9CFEC-4E94-46BD-9342-048F7082BE35 Q38596072-889D1264-2737-444D-AB46-16C45DEC974F Q38640885-BDD392E2-72FB-47FB-8B14-FD6611629DB9 Q39020200-8AC3E3AB-D0A7-4CE5-9881-E86DA5EE0305 Q42726357-234FCF9E-47B3-474F-A547-4FB7EAECA59B

P2860

Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels

http://www.wikidata.org/entity/Q34028692

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Disruption of hypothalamic lep ...... als stabilize adiposity levels

@ast

Disruption of hypothalamic lep ...... als stabilize adiposity levels

@en

Disruption of hypothalamic lep ...... als stabilize adiposity levels

@nl

type

label

Disruption of hypothalamic lep ...... als stabilize adiposity levels

@ast

Disruption of hypothalamic lep ...... als stabilize adiposity levels

@en

Disruption of hypothalamic lep ...... als stabilize adiposity levels

@nl

prefLabel

Disruption of hypothalamic lep ...... als stabilize adiposity levels

@ast

Disruption of hypothalamic lep ...... als stabilize adiposity levels

@en

Disruption of hypothalamic lep ...... als stabilize adiposity levels

@nl

P1433

Q34028692-A0AC0056-8FA5-4CA6-AC6E-6963C2C76424

P1476

Q34028692-AEBBEFD6-AEAF-4B64-8946-F49F1FDD7A6B

P2093

Q34028692-4F4E0261-C098-41AD-A63A-3C0140780E78

P2860

Q34028692-096655E6-809C-4C2B-9C1D-8A93CABB1D30

Q34028692-0A5A6783-5F68-4CC4-824F-89BA0C77BDF8

Q34028692-15B7EABA-AB6C-4A5A-93F8-3BF4FAC983EC

Q34028692-17EFC09A-2F4D-4F71-88FA-957DF6C01C41

Q34028692-21142D6F-A26D-4D0E-A410-920710ECABB1

Q34028692-21EF9748-6544-4041-817C-A17B51C5B1DB

Q34028692-24141707-4B8E-4FE5-B4AA-5142CE97070F

Q34028692-2A058F03-8057-455E-B82A-E4EEF893FD3D

Q34028692-2BA6E82B-C1E5-4125-A6B1-A57E09AA5EA0

Q34028692-2C1D2636-D44A-4885-9EEF-4AB3DBDAD7B7

P304

Q34028692-E5918895-27E2-48B8-BFA5-65BF3ED08C53

P31

Q34028692-43BAF6EC-C013-410A-9601-6DCCD5ABE06C

P356

Q34028692-6468F8DC-9469-4C50-A1B1-7C8FED1D29DA

P407

Q34028692-3D91429B-93C6-4BB0-92A6-BFA6AAB43518

P433

Q34028692-D9F40652-7516-4D10-98A9-7B04F8AEE206

P478

Q34028692-532D6E6E-389F-4433-92AE-479BA09B9217

P50

Q34028692-361D08A0-1CA5-4C51-9A1C-3E3990B0A886

P577

Q34028692-CADC08CF-223D-4465-97FC-5EE98C6B63B0

P698

Q34028692-8F2A4DF8-860E-471D-AF40-D01292C49C02

P921

Q34028692-2B43097D-0CEF-418D-8F9F-2043DD595BEF

P932

Q34028692-A7C4B8F4-9F87-43F0-97F2-399A6605AF02

P356

P1433

Journal of Clinical Investigation

P1476

Disruption of hypothalamic lep ...... als stabilize adiposity levels

@en

P2093

Lori M Zeltser

http://www.w3.org/2001/XMLSchema#string

P2860

Positional cloning of the mouse obese gene and its human homologue

From observation to experimentation: leptin action in the mediobasal hypothalamus

Generalized lacZ expression with the ROSA26 Cre reporter strain

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

Selective deletion of leptin receptor in neurons leads to obesity

Leptin receptor signaling in midbrain dopamine neurons regulates feeding

Intracellular signalling. Key enzyme in leptin-induced anorexia

Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

Prevalence and trends in obesity among US adults, 1999-2008

P304

2931-2941

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1172/JCI41985

http://www.w3.org/2001/XMLSchema#string

P407

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

120

http://www.w3.org/2001/XMLSchema#string

P50

Laurence E Ring

P577

2010-07-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

20592471

http://www.w3.org/2001/XMLSchema#string

P921

P932

2912188

http://www.w3.org/2001/XMLSchema#string