about
Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelAPhospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targetingManipulation of the host protein acetylation network by human immunodeficiency virus type 1Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic interventionRVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomainThe mechanisms behind the therapeutic activity of BET bromodomain inhibitionFunctions of BET proteins in erythroid gene expressionTargeting BET bromodomains for cancer treatmentBET domain co-regulators in obesity, inflammation and cancerBRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membraneUpdate from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Nasal Cavity, Paranasal Sinuses and Skull Base.Clinicopathologic features and long-term outcomes of NUT midline carcinoma.Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628Activation of SOX2 expression by BRD4-NUT oncogenic fusion drives neoplastic transformation in NUT midline carcinoma.BETs abet Tam-R in ER-positive breast cancer.Establishment and characterization of a new human extragonadal germ cell line, SEM-1, and its comparison with TCam-2 and JKT-1.The importance of diagnosing NUT midline carcinoma.PFI-1, a highly selective protein interaction inhibitor, targeting BET BromodomainsBiased multicomponent reactions to develop novel bromodomain inhibitors.Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulationMechanistic analysis of the role of bromodomain-containing protein 4 (BRD4) in BRD4-NUT oncoprotein-induced transcriptional activation.Cytological Features of a Variant NUT Midline Carcinoma of the Lung Harboring the NSD3-NUT Fusion Gene: A Case Report and Literature Review.Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic CharacterizationsReceptor-Independent Ectopic Activity of Prolactin Predicts Aggressive Lung Tumors and Indicates HDACi-Based Therapeutic Strategies.A Bead-Based Proximity Assay for BRD4 Ligand Discovery.Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4.Sinonasal NUT-Midline Carcinoma - A Multimodality Approach to Diagnosis, Staging and Post-Surgical Restaging.The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains.NUT expression in primary lung tumoursEffect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability.Pathologic characteristics of NUT midline carcinoma arising in the mediastinumThe Oncoprotein BRD4-NUT Generates Aberrant Histone Modification PatternsLandscape of gene fusions in epithelial cancers: seq and ye shall find.Nuclear protein in testis midline carcinoma misdiagnosed as adamantinoma.NUT Carcinoma of the Sublingual Gland.Bromodomain and extraterminal (BET) protein inhibition suppresses human T cell leukemia virus 1 (HTLV-1) Tax protein-mediated tumorigenesis by inhibiting nuclear factor κB (NF-κB) signalingA rare case of NUT midline carcinoma.Erythropoiesis provides a BRD's eye view of BET protein function.Brd4 and HEXIM1: multiple roles in P-TEFb regulation and cancer.Targeting BET bromodomain proteins in solid tumors
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Pathogenesis of NUT midline carcinoma.
@ast
Pathogenesis of NUT midline carcinoma.
@en
Pathogenesis of NUT midline carcinoma.
@nl
type
label
Pathogenesis of NUT midline carcinoma.
@ast
Pathogenesis of NUT midline carcinoma.
@en
Pathogenesis of NUT midline carcinoma.
@nl
prefLabel
Pathogenesis of NUT midline carcinoma.
@ast
Pathogenesis of NUT midline carcinoma.
@en
Pathogenesis of NUT midline carcinoma.
@nl
P1476
Pathogenesis of NUT midline carcinoma.
@en
P2093
Christopher A French
P304
P356
10.1146/ANNUREV-PATHOL-011811-132438
P577
2011-10-17T00:00:00Z