Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms
about
Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosisComplexins: small but capableReconstituting SNARE-mediated membrane fusion at the single liposome level.High Transmembrane Voltage Raised by Close Contact Initiates Fusion Pore.Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate ComplexinsMembrane Fusion Involved in Neurotransmission: Glimpse from Electron Microscope and Molecular Simulation.A distinct tethering step is vital for vacuole membrane fusion.The accessory helix of complexin functions by stabilizing central helix secondary structureSequential conformational rearrangements in flavivirus membrane fusion.Re-visiting the trans insertion model for complexin clamping.Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexinTowards reconstitution of membrane fusion mediated by SNAREs and other synaptic proteinsSynaptotagmin-1 C2B domain interacts simultaneously with SNAREs and membranes to promote membrane fusion.Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complexFunctional synergy between the Munc13 C-terminal C1 and C2 domains.N-terminal domain of complexin independently activates calcium-triggered fusion.C-terminal domain of mammalian complexin-1 localizes to highly curved membranes.Preincubation of t-SNAREs with Complexin I Increases Content-Mixing Efficiency.Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets.Calcium dependence of spontaneous neurotransmitter release.Reconstitution of calcium-mediated exocytosis of dense-core vesicles.Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function.Mechanisms, pools, and sites of spontaneous vesicle release at synapses of rod and cone photoreceptors.How does the stimulus define exocytosis in adrenal chromaffin cells?Advancing research.Complexin Binding to Membranes and Acceptor t-SNAREs Explains Its Clamping Effect on Fusion.Vesicle Fusion Mediated by Solanesol-Anchored DNA.Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.Productive and Non-productive Pathways for Synaptotagmin 1 to Support Ca2+-Triggered Fast Exocytosis.Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses.SNARE proteins in membrane trafficking.Hydrodynamics govern the pre-fusion docking time of synaptic vesicles.Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis.Accessory and Central α-helices of Complexin Selectively Activate Ca2+ Triggering of Synaptic Exocytosis.A mechanism for exocytotic arrest by the Complexin C-terminusFocused clamping of a single neuronal SNARE complex by complexin under high mechanical tension
P2860
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P2860
Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms
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2014 nî lūn-bûn
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2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2014 թվականի օգոստոսին հրատարակված գիտական հոդված
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年學術文章
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name
Complexin inhibits spontaneous ...... fusion by distinct mechanisms
@ast
Complexin inhibits spontaneous ...... fusion by distinct mechanisms
@en
Complexin inhibits spontaneous ...... fusion by distinct mechanisms
@nl
type
label
Complexin inhibits spontaneous ...... fusion by distinct mechanisms
@ast
Complexin inhibits spontaneous ...... fusion by distinct mechanisms
@en
Complexin inhibits spontaneous ...... fusion by distinct mechanisms
@nl
prefLabel
Complexin inhibits spontaneous ...... fusion by distinct mechanisms
@ast
Complexin inhibits spontaneous ...... fusion by distinct mechanisms
@en
Complexin inhibits spontaneous ...... fusion by distinct mechanisms
@nl
P2093
P2860
P356
P1433
P1476
Complexin inhibits spontaneous ...... fusion by distinct mechanisms
@en
P2093
Daniel J Cipriano
Mark S Padolina
Richard A Pfuetzner
Yunxiang Zhang
P2860
P304
P356
10.7554/ELIFE.03756
P407
P577
2014-08-13T00:00:00Z