2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase - Wikidata - wikimedia - TriplyDB

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

http://www.wikidata.org/entity/Q34035183

about

Dysregulated metabolism contributes to oncogenesis Pyruvate kinase: Function, regulation and role in cancer M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.Combining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activity How chemoproteomics can enable drug discovery and development PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2.Activators of PKM2 in cancer metabolism.A novel pyruvate kinase M2 activator compound that suppresses lung cancer cell viability under hypoxia Bioluminescence Methods for Assaying Kinases in Quantitative High-Throughput Screening (qHTS) Format Applied to Yes1 Tyrosine Kinase, Glucokinase, and PI5P4Kα Lipid Kinase.Anticancer agents that counteract tumor glycolysis.Global profiling strategies for mapping dysregulated metabolic pathways in cancer.Stalling the engine of resistance: targeting cancer metabolism to overcome therapeutic resistance.miR-122 targets pyruvate kinase M2 and affects metabolism of hepatocellular carcinoma Regulation and function of pyruvate kinase M2 in cancer.Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma.PKM2, a Central Point of Regulation in Cancer Metabolism.Pyruvate kinase activators as a therapy target: a patent review 2011-2017.Photoredox-catalyzed procedure for carbamoyl radical generation: 3,4-dihydroquinolin-2-one and quinolin-2-one synthesis.Inhibitory and Activating Effects of Some Flavonoid Derivatives on Human Pyruvate Kinase Isoenzyme M2.

P2860

Q26784630-3F5F4A65-8840-4CBC-B176-5A33A6BF58F5 Q26798084-27D0DEE3-29F6-487F-98EA-59F5B4082851 Q27677066-31B19A3F-7127-44D8-B58B-D8B7F675A146 Q28655910-90BA8856-4BFF-4A4C-BDEA-E4014E916B5D Q34143272-DAF6348F-F6A5-49A8-B37B-67DA9BBDE450 Q34498995-D5C7F8EB-43EE-4A19-A8AB-AA1D59895613 Q35215989-11F24764-2627-47FD-9A8A-37C3034C5E0D Q35450863-C395AD7B-0392-4BF4-BFE6-FCA561B77875 Q35821339-04AB9585-BAC4-4CE7-ADF8-9DE390124406 Q36452381-1DB92C3B-7A16-4E5B-8740-0BE11A1E9F81 Q36516956-86B6A825-F075-4DE6-B113-A237945A482D Q36815271-5A34C94D-99CC-4461-9AA9-DD98D67EDD6C Q37510658-440360F7-D1FC-4DDE-97E0-C4E5F2F50480 Q37631099-D80438E3-8C59-427C-852D-272F8DD46CAE Q38694204-A0FDC066-ACF8-45A4-B996-0FADC2588CCC Q41669982-8B1D2D7C-72C5-4139-B54B-951250B29E16 Q47673139-E285F36A-CB0F-40F2-AB54-FECC7EB0944A Q48198323-BF895087-053D-439A-BE63-33BD3AE88748 Q51589905-F5126F03-48C3-4884-9FC1-D06C897D56A2

P2860

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

http://www.wikidata.org/entity/Q34035183

description

2011 nî lūn-bûn

@nan

2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

2-Oxo-N-aryl-1,2,3,4-tetrahydr ...... M2 isoform of pyruvate kinase

@ast

2-Oxo-N-aryl-1,2,3,4-tetrahydr ...... M2 isoform of pyruvate kinase

@en

2-Oxo-N-aryl-1,2,3,4-tetrahydr ...... M2 isoform of pyruvate kinase

@nl

type

label

2-Oxo-N-aryl-1,2,3,4-tetrahydr ...... M2 isoform of pyruvate kinase

@ast

2-Oxo-N-aryl-1,2,3,4-tetrahydr ...... M2 isoform of pyruvate kinase

@en

2-Oxo-N-aryl-1,2,3,4-tetrahydr ...... M2 isoform of pyruvate kinase

@nl

prefLabel

2-Oxo-N-aryl-1,2,3,4-tetrahydr ...... M2 isoform of pyruvate kinase

@ast

2-Oxo-N-aryl-1,2,3,4-tetrahydr ...... M2 isoform of pyruvate kinase

@en

2-Oxo-N-aryl-1,2,3,4-tetrahydr ...... M2 isoform of pyruvate kinase

@nl

P1433

Q34035183-53D02500-B076-4FF0-AAAC-D32163E0596C

P1476

Q34035183-83294D0D-2CE8-4AFA-8E7F-81DA1302525A

P2093

Q34035183-1639A93D-0D5B-4BEC-8809-2B011A22B9CE

Q34035183-199FD795-083A-49FD-8320-EEAA8355C0C3

Q34035183-262F48F1-F800-4875-BDE2-FF2FC9F898E3

Q34035183-667FC7C4-39D7-4275-BE2D-EF601AB45284

Q34035183-82011EF0-E19B-45B8-A372-6D64A2AC2013

Q34035183-9732EE6D-D7D9-4299-B7DE-C7A2AF02E907

Q34035183-9F5D46B9-1394-4714-856C-28AD5F491F05

Q34035183-D2027BE2-4307-4C32-A4AC-5D754508A86C

Q34035183-EEB2A132-99A0-4ED2-908C-00F640684745

Q34035183-F72C9936-D793-47FD-AF4B-BC4B6901960C

P2860

Q34035183-04F4BE44-06C9-4A88-AC4D-2B67350345F2

Q34035183-1E3B2A86-888E-4000-A6E3-4D95AF826038

Q34035183-286D2FEB-E99B-45BC-8502-5E3F7A80A45C

Q34035183-5B13A8C6-B89F-4A00-8333-378182086F0D

Q34035183-600AD973-C1C1-4199-8101-965E9F9D0D90

Q34035183-71ACC7FE-3CF5-470C-BD16-7923E9797F22

Q34035183-7B341985-C695-4BD2-8B2C-B382F9B03C29

Q34035183-7D232622-143D-42ED-ABAB-3CAEB7A38015

Q34035183-7DF785AC-3403-4C26-B1BE-016D402EDBF5

Q34035183-83BAAE30-8FE9-4765-8165-887E390D80B2

P304

Q34035183-AED7EA98-5EB1-4804-A4D1-B4979E88B465

P31

Q34035183-E3E6CB64-1613-4772-82EC-47E740C2B62C

P356

Q34035183-272453D6-40B5-40C6-8DC8-10AF53AB2BE0

P407

Q34035183-8A4EFB44-9CC6-43E3-8789-C4C7D4699CDF

P433

Q34035183-49FF4DF5-E943-4024-B634-0C60DB1F4B9F

P478

Q34035183-892CDE94-53FE-4E0D-9845-E9D7CD24AFC8

P50

Q34035183-7ABD4ABD-0A7E-4B30-A37D-C8F8B946A187

Q34035183-B561B775-78D0-4EC7-BF9B-76067E1768A4

P577

Q34035183-530D7E4B-EAA2-4B49-B357-923B02610B77

P5875

Q34035183-DD1FE8E9-D1D3-4EF3-9A0F-258BD08910D6

P698

Q34035183-BF1C9BCC-AB2D-47FE-9714-7592CB9213C0

P932

Q34035183-D719D6AE-1295-49A3-B972-F6A22E4BF068

P356

J.BMCL.2011.08.114

P1433

Bioorganic & Medicinal Chemistry Letters

P1476

2-Oxo-N-aryl-1,2,3,4-tetrahydr ...... M2 isoform of pyruvate kinase

@en

P2093

Craig J Thomas

http://www.w3.org/2001/XMLSchema#string

Douglas S Auld

http://www.w3.org/2001/XMLSchema#string

Henrike Veith

http://www.w3.org/2001/XMLSchema#string

James M Bougie

http://www.w3.org/2001/XMLSchema#string

Kyle R Brimacombe

http://www.w3.org/2001/XMLSchema#string

Martin J Walsh

http://www.w3.org/2001/XMLSchema#string

Matthew B Boxer

http://www.w3.org/2001/XMLSchema#string

Matthew G Vander Heiden

http://www.w3.org/2001/XMLSchema#string

Min Shen

http://www.w3.org/2001/XMLSchema#string

Thomas Daniel

http://www.w3.org/2001/XMLSchema#string

P2860

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

Understanding the Warburg effect: the metabolic requirements of cell proliferation

Pyruvate kinase M2 is a phosphotyrosine-binding protein

Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

Pyruvate kinase type M2 and its role in tumor growth and spreading

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing.

P304

6322-6327

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.BMCL.2011.08.114

http://www.w3.org/2001/XMLSchema#string

P407

P433

21

http://www.w3.org/2001/XMLSchema#string

P478

21

http://www.w3.org/2001/XMLSchema#string

P50

Lewis C. Cantley

William J Israelsen

P577

2011-09-14T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51680797

http://www.w3.org/2001/XMLSchema#string

P698

21958545

http://www.w3.org/2001/XMLSchema#string

P932

3224553

http://www.w3.org/2001/XMLSchema#string