Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells. - Wikidata - wikimedia - TriplyDB

Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells.

Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells.

http://www.wikidata.org/entity/Q34035257

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One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling Translational development of difluoromethylornithine (DFMO) for the treatment of neuroblastoma Tpo1-mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response.An inverse small molecule screen to design a chemically defined medium supporting long-term growth of Drosophila cell lines Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development.Biochemical quantitation of the eIF5A hypusination in Arabidopsis thaliana uncovers ABA-dependent regulation The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly The polyamine catabolic enzyme SAT1 modulates tumorigenesis and radiation response in GBM A metabolomic approach to identifying platinum resistance in ovarian cancer.Local de-condensation of double-stranded DNA in oppositely charged polyelectrolyte as induced by spermidine.Cotton polyamine oxidase is required for spermine and camalexin signalling in the defence response to Verticillium dahliae.The Trypanosoma cruzi Diamine Transporter Is Essential for Robust Infection of Mammalian Cells.Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermine N¹-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells.Biodiversity of Intestinal Lactic Acid Bacteria in the Healthy Population.Decreased sensitivity to aspirin is associated with altered polyamine metabolism in human prostate cancer cells.Metabolomics reveals aging-associated attenuation of noninvasive radiation biomarkers in mice: potential role of polyamine catabolism and incoherent DNA damage-repair.Polyamines and their metabolites as diagnostic markers of human diseases.Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses.Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer.Genome-scale RNA interference screen identifies antizyme 1 (OAZ1) as a target for improvement of recombinant protein production in mammalian cells.Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/β-catenin signaling pathways in hepatocellular and colorectal carcinoma cells.Polyamine catabolism in carcinogenesis: potential targets for chemotherapy and chemoprevention.The role of glia in stress: polyamines and brain disorders Identification of two natural compound inhibitors of Leishmania donovani Spermidine Synthase (SpdS) through molecular docking and dynamic studies.Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance.The mammalian blastocyst.Arginine dependence of tumor cells: targeting a chink in cancer's armor.Protective Effect of Lactobacillus casei on DMH-Induced Colon Carcinogenesis in Mice.Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells.Polyamine stimulation of eEF1A synthesis based on the unusual position of a complementary sequence to 18S rRNA in eEF1A mRNA.Ser/Thr kinases and polyamines in the regulation of non-canonical functions of elongation factor 1A.The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A.Identification of differentially regulated maize proteins conditioning Sugarcane mosaic virus systemic infection.Cotton ACAULIS5 is involved in stem elongation and the plant defense response to Verticillium dahliae through thermospermine alteration.Metabolic heterogeneity of idiopathic pulmonary fibrosis: a metabolomic study Complementary ACSL isoforms contribute to a non-Warburg advantageous energetic status characterizing invasive colon cancer cells.Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1.Ornithine decarboxylase as a therapeutic target for endometrial cancer.Amniotic Fluid Arginine from Gestational Weeks 13 to 15 Is a Predictor of Birth Weight, Length, and Head Circumference.

P2860

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P2860

Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells.

http://www.wikidata.org/entity/Q34035257

description

2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013 թվականի հունվարին հրատարակված գիտական հոդված

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2013年の論文

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name

Depletion of cellular polyamin ...... and growth in mammalian cells.

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Depletion of cellular polyamin ...... and growth in mammalian cells.

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Depletion of cellular polyamin ...... and growth in mammalian cells.

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type

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Depletion of cellular polyamin ...... and growth in mammalian cells.

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Depletion of cellular polyamin ...... and growth in mammalian cells.

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Depletion of cellular polyamin ...... and growth in mammalian cells.

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Depletion of cellular polyamin ...... and growth in mammalian cells.

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Depletion of cellular polyamin ...... and growth in mammalian cells.

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Depletion of cellular polyamin ...... and growth in mammalian cells.

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PNAS.1219002110

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Depletion of cellular polyamin ...... and growth in mammalian cells.

@en

P2093

Ajeet Mandal

http://www.w3.org/2001/XMLSchema#string

Arturo V Orjalo

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Myung Hee Park

http://www.w3.org/2001/XMLSchema#string

Swati Mandal

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P2860

The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A)

Hypusine-containing protein eIF5A promotes translation elongation

eIF5A has a function in the elongation step of translation in yeast.

Functional significance of eIF5A and its hypusine modification in eukaryotes

The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation

Suppression of exogenous gene expression by spermidine/spermine N1-acetyltransferase 1 (SSAT1) cotransfection.

Modulation of cellular function by polyamines.

Polyamines and cancer: old molecules, new understanding.

Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1).

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scholarly article

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10.1073/PNAS.1219002110

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6

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110

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Hans E Johansson

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2013-01-23T00:00:00Z

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235220793

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3568356

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