The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies?
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RNA-Mediated Regulation of HMGA1 FunctionHMGA1 pseudogenes as candidate proto-oncogenic competitive endogenous RNAsSTAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious.HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell nicheThe High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development.Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1.Herbal extract SH003 suppresses tumor growth and metastasis of MDA-MB-231 breast cancer cells by inhibiting STAT3-IL-6 signaling.HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesisHMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cellsLIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers.Trichomonosis, a common curable STI, and prostate carcinogenesis--a proposed molecular mechanism.HMGA1 reprograms somatic cells into pluripotent stem cells by inducing stem cell transcriptional networks.HMGB1 in health and disease.HMGA1: a master regulator of tumor progression in triple-negative breast cancer cellsPhase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias.HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma.3'UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice.Nanoparticle delivery of inhibitory signal transducer and activator of transcription 3 G-quartet oligonucleotides blocks tumor growth in HMGA1 transgenic model of T-cell leukemia.The high mobility group A1 molecular switch: turning on cancer - can we turn it off?Flavopiridol induces BCL-2 expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia.MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2.Increased angiogenesis is associated with a 32-gene expression signature and 6p21 amplification in aggressive endometrial cancer.Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells.Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes.The HMGA1-COX-2 axis: a key molecular pathway and potential target in pancreatic adenocarcinoma.The Wnt/β-catenin/T-cell factor 4 pathway up-regulates high-mobility group A1 expression in colon cancerHMGA1 levels influence mitochondrial function and mitochondrial DNA repair efficiencyFibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival.The high mobility group A1 gene: transforming inflammatory signals into cancer?Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells.MicroRNA-214 suppresses growth, migration and invasion through a novel target, high mobility group AT-hook 1, in human cervical and colorectal cancer cells.Targeting signal transducer and activator of transcription 3 contributes to the solamargine-inhibited growth and -induced apoptosis of human lung cancer cells.Cryptotanshinone inhibits human glioma cell proliferation by suppressing STAT3 signaling.Computational Detection of Stage-Specific Transcription Factor Clusters during Heart Development.Upregulation of MMP-2 by HMGA1 promotes transformation in undifferentiated, large-cell lung cancer.The High Mobility Group A1 (HMGA1) gene is highly overexpressed in human uterine serous carcinomas and carcinosarcomas and drives Matrix Metalloproteinase-2 (MMP-2) in a subset of tumors.Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells.HMGA1 overexpression correlates with relapse in childhood B-lineage acute lymphoblastic leukemia.Annotation enrichment analysis: an alternative method for evaluating the functional properties of gene sets.Hitting the bull's eye: targeting HMGA1 in cancer stem cells.
P2860
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P2860
The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies?
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The high-mobility group A1a/si ...... or hematopoietic malignancies?
@ast
The high-mobility group A1a/si ...... or hematopoietic malignancies?
@en
The high-mobility group A1a/si ...... or hematopoietic malignancies?
@nl
type
label
The high-mobility group A1a/si ...... or hematopoietic malignancies?
@ast
The high-mobility group A1a/si ...... or hematopoietic malignancies?
@en
The high-mobility group A1a/si ...... or hematopoietic malignancies?
@nl
prefLabel
The high-mobility group A1a/si ...... or hematopoietic malignancies?
@ast
The high-mobility group A1a/si ...... or hematopoietic malignancies?
@en
The high-mobility group A1a/si ...... or hematopoietic malignancies?
@nl
P2093
P2860
P1433
P1476
The high-mobility group A1a/si ...... or hematopoietic malignancies?
@en
P2093
Amy Belton
Francescopaolo Di Cello
James Turkson
Joelle Hillion
Kelsey Wertzler
Linda M S Resar
Linzhao Cheng
Mita Mukherjee
Ossama Elbahlouh
Peter Aplan
P2860
P304
10121-10127
P356
10.1158/0008-5472.CAN-08-2121
P407
P577
2008-12-01T00:00:00Z