APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells. - Wikidata - wikimedia - TriplyDB

APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.

APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.

http://www.wikidata.org/entity/Q34037651

about

SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection AID and APOBECs span the gap between innate and adaptive immunity New insights into an X-traordinary viral protein SAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx Protein SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates Molecular mechanisms of HIV immune evasion of the innate immune response in myeloid cells Suppression of APOBEC3-mediated restriction of HIV-1 by Vif Macrophage polarization in health and disease NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n A DNA sequence recognition loop on APOBEC3A controls substrate specificity Different mutagenic potential of HIV-1 restriction factors APOBEC3G and APOBEC3F is determined by distinct single-stranded DNA scanning mechanisms Intrinsic cellular defenses against human immunodeficiency viruses Transient overexpression of exogenous APOBEC3A causes C-to-U RNA editing of thousands of genes.Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.17β-estradiol protects primary macrophages against HIV infection through induction of interferon-alpha.Different modes of retrovirus restriction by human APOBEC3A and APOBEC3G in vivo.A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral Vif.MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1 Differential effects of Vpr on single-cycle and spreading HIV-1 infections in CD4+ T-cells and dendritic cells.Novel factors interfering with human immunodeficiency virus-type 1 replication in vivo and in vitro.Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death.Distinct characteristics of endometrial and decidual macrophages and regulation of their permissivity to HIV-1 infection by SAMHD1.Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation Select host restriction factors are associated with HIV persistence during antiretroviral therapy.APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages Eradication of HIV-1 from the macrophage reservoir: an uncertain goal?The Frequency of Cytidine Editing of Viral DNA Is Differentially Influenced by Vpx and Nucleosides during HIV-1 or SIVMAC Infection of Dendritic Cells.Stress-activated Dendritic Cells (DC) Induce Dual Interleukin (IL)-15- and IL1β-mediated Pathways, Which May Elicit CD4+ Memory T Cells and Interferon (IFN)-stimulated Genes.APOBEC3 versus Retroviruses, Immunity versus Invasion: Clash of the Titans.Antiviral gene expression in psoriasis.Retroelements versus APOBEC3 family members: No great escape from the magnificent seven Biochemical analysis of hypermutation by the deoxycytidine deaminase APOBEC3A.Technical advance: liposomal alendronate depletes monocytes and macrophages in the nonhuman primate model of human disease APOBEC3 Proteins in Viral Immunity.Functional analysis of the relationship between Vpx and the restriction factor SAMHD1.SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons Inhibition of reverse transcriptase activity increases stability of the HIV-1 core.TLR-4 engagement of dendritic cells confers a BST-2/tetherin-mediated restriction of HIV-1 infection to CD4+ T cells across the virological synapse.Evidence for IFNα-induced, SAMHD1-independent inhibitors of early HIV-1 infection.

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APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.

http://www.wikidata.org/entity/Q34037651

description

2011 nî lūn-bûn

@nan

2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.

@ast

APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.

@en

APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.

@nl

type

label

APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.

@ast

APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.

@en

APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.

@nl

prefLabel

APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.

@ast

APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.

@en

APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.

@nl

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JOURNAL.PPAT.1002221

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P1476

APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells

@en

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Delphine Muriaux

http://www.w3.org/2001/XMLSchema#string

Gregory Berger

http://www.w3.org/2001/XMLSchema#string

Guillaume Fargier

http://www.w3.org/2001/XMLSchema#string

Jean-Luc Darlix

http://www.w3.org/2001/XMLSchema#string

Serge Bouaziz

http://www.w3.org/2001/XMLSchema#string

Stéphanie Cordeil

http://www.w3.org/2001/XMLSchema#string

Stéphanie Durand

http://www.w3.org/2001/XMLSchema#string

Xuan-Nhi Nguyen

http://www.w3.org/2001/XMLSchema#string

P2860

APOBEC3 proteins mediate the clearance of foreign DNA from human cells

HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase

The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons

Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities

Antiretroelement activity of APOBEC3H was lost twice in recent human evolution

The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion.

APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells

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e1002221

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scholarly article

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10.1371/JOURNAL.PPAT.1002221

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9

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7

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Andrea Cimarelli

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2011-09-22T00:00:00Z

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51687389

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21966267

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3178557

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