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Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes.

Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes.

http://www.wikidata.org/entity/Q34046778

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Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens A Pipeline for Drug Target Identification and Validation Flexible CRISPR library construction using parallel oligonucleotide retrieval.Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62 Prediction of potent shRNAs with a sequential classification algorithm.Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.A permutation-based non-parametric analysis of CRISPR screen data.Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells.Genetic compensation: A phenomenon in search of mechanisms.modPhEA: model organism Phenotype Enrichment Analysis of eukaryotic gene sets.Applications of CRISPR genome editing technology in drug target identification and validation.Future of rAAV Gene Therapy: Platform for RNAi, Gene Editing, and Beyond.Genetic interaction mapping in mammalian cells using CRISPR interference.Large-scale image-based screening and profiling of cellular phenotypes.Applications of CRISPR Genome Engineering in Cell Biology.Cornerstones of CRISPR-Cas in drug discovery and therapy.Multiplexed Gene Editing and Protein Overexpression Using a Tobacco mosaic virus Viral Vector.Prediction and analysis of essential genes using the enrichments of gene ontology and KEGG pathways.Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism DOCK6 inactivation highlights ISGylation as RHO-GTPase balancer.LncRNA MALAT1 Inhibits Apoptosis and Promotes Invasion by Antagonizing miR-125b in Bladder Cancer Cells.mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay.CRISPR/Cas9 Genome-Editing System in Human Stem Cells: Current Status and Future Prospects.A Comprehensive Overview of Online Resources to Identify and Predict Bacterial Essential Genes.Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy.Next-Generation Sequencing of Genome-Wide CRISPR Screens.Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators.Am I ready for CRISPR? A user's guide to genetic screens.Combined shRNA over CRISPR/cas9 as a methodology to detect off-target effects and a potential compensatory mechanism.A Comprehensive Protocol Resource for Performing Pooled shRNA and CRISPR Screens.Acute multi-sgRNA knockdown of KEOPS complex genes reproduces the microcephaly phenotype of the stable knockout zebrafish model.Identification of DISE-inducing shRNAs by monitoring cellular responses.Lactobacillus gasseri CRISPR-Cas9 characterization In Vitro reveals a flexible mode of protospacer-adjacent motif recognition.A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.Toward an integrated map of genetic interactions in cancer cells.Mechanism of cell-intrinsic adaptation to Adams-Oliver Syndrome gene DOCK6 disruption highlights ubiquitin-like modifier ISG15 as a regulator of RHO GTPases.Comparing CRISPR and RNAi-based screening technologies.

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P2860

Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes.

http://www.wikidata.org/entity/Q34046778

description

2016 nî lūn-bûn

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2016 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2016 թվականի մայիսին հրատարակված գիտական հոդված

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2016年の論文

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2016年论文

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Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes.

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Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes.

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Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes.

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type

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Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes.

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Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes.

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Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes.

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Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes.

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Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes.

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Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes.

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Nature Biotechnology

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Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes.

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Amy Li

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David W Morgens

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Michael C Bassik

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Richard M Deans

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An integrated encyclopedia of DNA elements in the human genome

Statistical methods for analysis of high-throughput RNA interference screens

Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

Expression profiling reveals off-target gene regulation by RNAi

Genome-scale CRISPR-Cas9 knockout screening in human cells

Saccharomyces Genome Database: the genomics resource of budding yeast

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

Genetic screens in human cells using the CRISPR-Cas9 system

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