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Mutator suppression and escape from replication error-induced extinction in yeast

Mutator suppression and escape from replication error-induced extinction in yeast

http://www.wikidata.org/entity/Q34055320

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Implications of genetic heterogeneity in cancer DNA polymerase ε and its roles in genome stability Do mutator mutations fuel tumorigenesis?DNA polymerase delta in DNA replication and genome maintenance Antimutator variants of DNA polymerases Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice Replicative DNA polymerase δ but not ε proofreads errors in Cis and in Trans A panoply of errors: polymerase proofreading domain mutations in cancer DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer DNA replication error-induced extinction of diploid yeast Genome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminase Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variant Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in Saccharomyces cerevisiae.Volatility of Mutator Phenotypes at Single Cell Resolution Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Quantifying the contributions of base selectivity, proofreading and mismatch repair to nuclear DNA replication in Saccharomyces cerevisiae.Emergence of DNA polymerase ε antimutators that escape error-induced extinction in yeast.Hypermutability and error catastrophe due to defects in ribonucleotide reductase.Mutation tendency of mutator Plasmodium berghei with proofreading-deficient DNA polymerase δ Darwinism for the Genomic Age: Connecting Mutation to Diversification.Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase δ mutation in human cells.Genomic Instability in Cancer: Teetering on the Limit of Tolerance.Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis.DNA Repair Is Associated with Information Content in Bacteria, Archaea, and DNA Viruses.A common cancer-associated DNA polymerase ε mutation causes an exceptionally strong mutator phenotype, indicating fidelity defects distinct from loss of proofreading.Comprehensive Analysis of Hypermutation in Human Cancer.Stress-induced cellular adaptive strategies: ancient evolutionarily conserved programs as new anticancer therapeutic targets.Recombination Is Responsible for the Increased Recovery of Drug-Resistant Mutants with Hypermutated Genomes in Resting Yeast Diploids Expressing APOBEC Deaminases.Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair.Nutrient-dependent growth defects and mutability of mutators in Escherichia coli.Generation of Immortalised But Unstable Cells after hTERT Introduction in Telomere-Compromised and p53-Deficient vHMECs

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Mutator suppression and escape from replication error-induced extinction in yeast

http://www.wikidata.org/entity/Q34055320

description

2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Mutator suppression and escape from replication error-induced extinction in yeast

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Mutator suppression and escape from replication error-induced extinction in yeast

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Mutator suppression and escape from replication error-induced extinction in yeast

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type

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Mutator suppression and escape from replication error-induced extinction in yeast

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Mutator suppression and escape from replication error-induced extinction in yeast

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Mutator suppression and escape from replication error-induced extinction in yeast

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prefLabel

Mutator suppression and escape from replication error-induced extinction in yeast

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Mutator suppression and escape from replication error-induced extinction in yeast

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Mutator suppression and escape from replication error-induced extinction in yeast

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JOURNAL.PGEN.1002282

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Mutator suppression and escape from replication error-induced extinction in yeast

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P2093

Alan J Herr

http://www.w3.org/2001/XMLSchema#string

Bradley D Preston

http://www.w3.org/2001/XMLSchema#string

Julie M Eggington

http://www.w3.org/2001/XMLSchema#string

Lindsey N Williams

http://www.w3.org/2001/XMLSchema#string

Mallika Singh

http://www.w3.org/2001/XMLSchema#string

Masanori Ogawa

http://www.w3.org/2001/XMLSchema#string

Nicole A Lawrence

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Robert A Smith

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P2860

Microbial genetics: Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation

Rates of spontaneous mutation

Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta

The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases

Human cancers express a mutator phenotype

Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations

Functional profiling of the Saccharomyces cerevisiae genome

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

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10

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22022273

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3188538

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