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Functional kinomics identifies candidate therapeutic targets in head and neck cancer

Functional kinomics identifies candidate therapeutic targets in head and neck cancer

http://www.wikidata.org/entity/Q34055936

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Molecular Aspects of Head and Neck Cancer Therapy Transforming Big Data into Cancer-Relevant Insight: An Initial, Multi-Tier Approach to Assess Reproducibility and Relevance.Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma.Genomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing.Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence.Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins.Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2.PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment.Emerging biomarkers in head and neck cancer in the era of genomics.Toward precision medicine in glioblastoma: the promise and the challenges.Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors.Integrating functional genomics to accelerate mechanistic personalized medicine.3q26-29 Amplification in head and neck squamous cell carcinoma: a review of established and prospective oncogenes.Molecularly targeted therapies for p53-mutant cancers.Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity.CHK it out! Blocking WEE kinase routs TP53 mutant cancer.CTD2 Dashboard: a searchable web interface to connect validated results from the Cancer Target Discovery and Development Network.New therapeutic strategies to treat human cancers expressing mutant p53 proteins.Identifying Genetic Dependencies in Cancer by Analyzing siRNA Screens in Tumor Cell Line Panels.Strategies for Targeted Therapy in Head and Neck Squamous Cell Carcinoma Using WEE1 Inhibitor AZD1775.A Phase I Clinical Trial of AZD1775 in Combination With Neoadjuvant Weekly Docetaxel and Cisplatin Before Definitive Therapy in Head and Neck Squamous Cell Carcinoma.Functional precision medicine identifies novel druggable targets and therapeutic options in head and neck cancer.Combination of lutetium-177 labelled anti-L1CAM antibody chCE7 with the clinically relevant protein kinase inhibitor MK1775: a novel combination against human ovarian carcinoma

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P2860

Functional kinomics identifies candidate therapeutic targets in head and neck cancer

http://www.wikidata.org/entity/Q34055936

description

2014 nî lūn-bûn

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2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Functional kinomics identifies candidate therapeutic targets in head and neck cancer

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Functional kinomics identifies candidate therapeutic targets in head and neck cancer

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Functional kinomics identifies candidate therapeutic targets in head and neck cancer

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type

label

Functional kinomics identifies candidate therapeutic targets in head and neck cancer

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Functional kinomics identifies candidate therapeutic targets in head and neck cancer

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Functional kinomics identifies candidate therapeutic targets in head and neck cancer

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Functional kinomics identifies candidate therapeutic targets in head and neck cancer

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Functional kinomics identifies candidate therapeutic targets in head and neck cancer

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Functional kinomics identifies candidate therapeutic targets in head and neck cancer

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Clinical Cancer Research

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Functional kinomics identifies candidate therapeutic targets in head and neck cancer

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Adam A Margolin

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Asel Biktasova

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Carla Grandori

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Chang Xu

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Christopher J Kemp

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Christopher M Schaupp

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Eduardo Méndez

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In Sock Jang

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James Annis

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Kay E Gurley

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P2860

Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts

Nek4 status differentially alters sensitivity to distinct microtubule poisons

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

Statistical methods for analysis of high-throughput RNA interference screens

p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways

TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence.

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase

Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis

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