Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation - Wikidata - wikimedia - TriplyDB

Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation

Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation

http://www.wikidata.org/entity/Q34056010

about

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1 An extensive network of information flow through the B1b/c intersubunit bridge of the yeast ribosome The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein ATM-dependent E2F1 accumulation in the nucleolus is an indicator of ribosomal stress in early response to DNA damage.The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications Ribosomal proteins: functions beyond the ribosome Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress A microarray-based gene expression analysis to identify diagnostic biomarkers for unknown primary cancer Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress.Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation Growth inhibitory effects of large subunit ribosomal proteins in melanoma.Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF.Mammalian HCA66 protein is required for both ribosome synthesis and centriole duplication Important genes in the pathogenesis of 5q- syndrome and their connection with ribosomal stress and the innate immune system pathway.Depletion of ribosomal protein L37 occurs in response to DNA damage and activates p53 through the L11/MDM2 pathway.Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis.Scission of the p53-MDM2 Loop by Ribosomal Proteins.Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.p53 -Dependent and -Independent Nucleolar Stress Responses.Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway.MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation.Probing the mechanisms underlying human diseases in making ribosomes.Down-regulation of ribosomal protein L22 in non-small cell lung cancer.Recruitment of RPL11 at promoter sites of p53-regulated genes upon nucleolar stress through NEDD8 and in an Mdm2-dependent manner.Ribosomal protein S14 unties the MDM2-p53 loop upon ribosomal stress.RP-MDM2-p53 Pathway: Linking Ribosomal Biogenesis and Tumor Surveillance.Inhibition of post-transcriptional steps in ribosome biogenesis confers cytoprotection against chemotherapeutic agents in a p53-dependent manner.Ribosomal protein L4 is a novel regulator of the MDM2-p53 loop.Balanced production of ribosome components is required for proper G1/S transition in Saccharomyces cerevisiae.The ribosomal protein S26 regulates p53 activity in response to DNA damage.Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism.Cancer-mutated ribosome protein L22 (RPL22/eL22) suppresses cancer cell survival by blocking p53-MDM2 circuit.Two Nucleolar Proteins, GDP1 and OLI2, Function As Ribosome Biogenesis Factors and Are Preferentially Involved in Promotion of Leaf Cell Proliferation without Strongly Affecting Leaf Adaxial-Abaxial Patterning in Arabidopsis thaliana.

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P2860

Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation

http://www.wikidata.org/entity/Q34056010

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Perturbation of 60 S ribosomal ...... d L11-dependent p53 activation

@ast

Perturbation of 60 S ribosomal ...... d L11-dependent p53 activation

@en

Perturbation of 60 S ribosomal ...... d L11-dependent p53 activation

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type

label

Perturbation of 60 S ribosomal ...... d L11-dependent p53 activation

@ast

Perturbation of 60 S ribosomal ...... d L11-dependent p53 activation

@en

Perturbation of 60 S ribosomal ...... d L11-dependent p53 activation

@nl

prefLabel

Perturbation of 60 S ribosomal ...... d L11-dependent p53 activation

@ast

Perturbation of 60 S ribosomal ...... d L11-dependent p53 activation

@en

Perturbation of 60 S ribosomal ...... d L11-dependent p53 activation

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JBC.M109.098442

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Journal of Biological Chemistry

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Perturbation of 60 S ribosomal ...... d L11-dependent p53 activation

@en

P2093

Dimitris P Xirodimas

http://www.w3.org/2001/XMLSchema#string

Mu-Shui Dai

http://www.w3.org/2001/XMLSchema#string

Xiao-Xin Sun

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Yue-Gang Wang

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P2860

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function

Regulation of nucleolar signalling to p53 through NEDDylation of L11

Ribosomal proteins are targets for the NEDD8 pathway

Inhibition of c-Myc activity by ribosomal protein L11

MDMX regulation of p53 response to ribosomal stress

Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

Inhibition of HDM2 and activation of p53 by ribosomal protein L23

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

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25812-25821

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scholarly article

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10.1074/JBC.M109.098442

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33

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285

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2010-06-16T00:00:00Z

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2919143

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