Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials.
about
Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug designNew drug target in protozoan parasites: the role of thioredoxin reductaseComparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruziA gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibitionThe Crystal Structures of the Tryparedoxin-Tryparedoxin Peroxidase Couple Unveil the Structural Determinants of Leishmania Detoxification PathwayInhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania infantum ProliferationPentavalent antimonials: new perspectives for old drugsDual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovaniLinking in vitro and in vivo survival of clinical Leishmania donovani strainsAntimonial resistance in Leishmania donovani is associated with increased in vivo parasite burdenMolecular mechanisms of drug resistance in natural Leishmania populations vary with genetic backgroundRole of efflux pumps and intracellular thiols in natural antimony resistant isolates of Leishmania donovaniGenetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress ManagementDrug resistance in leishmaniasisHigh-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.Molecular Docking and in Vitro Antileishmanial Evaluation of Chromene-2-thione Analogues.The parasite-specific trypanothione metabolism of trypanosoma and leishmania.Association of liposome-encapsulated trivalent antimonial with ascorbic acid: an effective and safe strategy in the treatment of experimental visceral leishmaniasis.Heterogeneity of molecular resistance patterns in antimony-resistant field isolates of Leishmania species from the western Mediterranean area.The in vivo susceptibility of Leishmania donovani to sodium stibogluconate is drug specific and can be reversed by inhibiting glutathione biosynthesisUse of antimony in the treatment of leishmaniasis: current status and future directions.Possible links between sickle cell crisis and pentavalent antimony.Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survivalPolyamine metabolism in Leishmania: from arginine to trypanothione.Leishmania antimony resistance: what we know what we can learn from the field.Drug-resistant microorganisms with a higher fitness--can medicines boost pathogens?Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania.Polyamine-trypanothione pathway: an update.Cutaneous leishmaniasis: therapeutic strategies and future directions.Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonialsThe Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite.Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase.Two conformationally vicinal thiols at the active site of Leishmania donovani adenosine kinase.Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates.A comparative study of methylglyoxal metabolism in trypanosomatids.Inducible resistance to oxidant stress in the protozoan Leishmania chagasi.Characterisation of a Putative Glutamate 5- Kinase from Leishmania donovani.8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase
P2860
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P2860
Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials.
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Trypanothione reductase from L ...... tion by trivalent antimonials.
@ast
Trypanothione reductase from L ...... tion by trivalent antimonials.
@en
Trypanothione reductase from L ...... tion by trivalent antimonials.
@nl
type
label
Trypanothione reductase from L ...... tion by trivalent antimonials.
@ast
Trypanothione reductase from L ...... tion by trivalent antimonials.
@en
Trypanothione reductase from L ...... tion by trivalent antimonials.
@nl
prefLabel
Trypanothione reductase from L ...... tion by trivalent antimonials.
@ast
Trypanothione reductase from L ...... tion by trivalent antimonials.
@en
Trypanothione reductase from L ...... tion by trivalent antimonials.
@nl
P2860
P1433
P1476
Trypanothione reductase from L ...... tion by trivalent antimonials.
@en
P2093
A H Fairlamb
M L Cunningham
P2860
P304
P356
10.1111/J.1432-1033.1995.TB20583.X
P407
P577
1995-06-01T00:00:00Z