RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects
about
Cancer systems biology: a network modeling perspectiveSimilar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistanceMulti-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epitheliumHow do oncoprotein mutations rewire protein-protein interaction networks?TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors.Systems analysis of small signaling modules relevant to eight human diseasesUsing partial least squares regression to analyze cellular response data.S100A4 and its role in metastasis – computational integration of data on biological networks.Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expressionPlasticity of the MAPK signaling network in response to mechanical stress.Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer.Multiscale analysis of the murine intestine for modeling human diseases.Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation.A multivariate model of ErbB network composition predicts ovarian cancer cell response to canertinibRadiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancerIn vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs.Network quantification of EGFR signaling unveils potential for targeted combination therapy.Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α.Multi-pathway network analysis of mammalian epithelial cell responses in inflammatory environments.Understanding resistance to combination chemotherapy.Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244)Differential gene expression of chemokines in KRAS and BRAF mutated colorectal cell lines: role of cytokines.Partial Least Squares Regression Models for the Analysis of Kinase Signaling.Integrating network reconstruction with mechanistic modeling to predict cancer therapies.CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling.Role of ERK-MAPK signaling pathway in pentagastrin-regulated growth of large intestinal carcinoma.Inhibition of colon cancer growth by docosahexaenoic acid involves autocrine production of TNFα.Mutations in K-ras and epidermal growth factor receptor expression in Korean patients with stages III and IV colorectal cancer.
P2860
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P2860
RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
RAS mutations affect tumor nec ...... g with non-ERK pathway effects
@ast
RAS mutations affect tumor nec ...... g with non-ERK pathway effects
@en
RAS mutations affect tumor nec ...... g with non-ERK pathway effects
@nl
type
label
RAS mutations affect tumor nec ...... g with non-ERK pathway effects
@ast
RAS mutations affect tumor nec ...... g with non-ERK pathway effects
@en
RAS mutations affect tumor nec ...... g with non-ERK pathway effects
@nl
prefLabel
RAS mutations affect tumor nec ...... g with non-ERK pathway effects
@ast
RAS mutations affect tumor nec ...... g with non-ERK pathway effects
@en
RAS mutations affect tumor nec ...... g with non-ERK pathway effects
@nl
P2093
P2860
P1433
P1476
RAS mutations affect tumor nec ...... g with non-ERK pathway effects
@en
P2093
Kevin M Haigis
Roli Mandhana
Shannon K Alford
P2860
P304
P356
10.1158/0008-5472.CAN-09-1921
P407
P577
2009-09-29T00:00:00Z