Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism. - Wikidata - wikimedia - TriplyDB

Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism.

Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism.

http://www.wikidata.org/entity/Q34084972

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Reactivity of thioredoxin as a protein thiol-disulfide oxidoreductase Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects Structural and Biochemical Studies Reveal Differences in the Catalytic Mechanisms of Mammalian and Drosophila melanogaster Thioredoxin Reductases †Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1 Mapping the Catalytic Cycle of Schistosoma mansoni Thioredoxin Glutathione Reductase by X-ray Crystallography Crystal structure of the human thioredoxin reductase-thioredoxin complex Structure of RdxA--an oxygen-insensitive nitroreductase essential for metronidazole activation in Helicobacter pylori Differing views of the role of selenium in thioredoxin reductase TrxR1 as a potent regulator of the Nrf2-Keap1 response system Selenium and its supplementation in cardiovascular disease--what do we know?Truncated mutants of human thioredoxin reductase 1 do not exhibit glutathione reductase activity Evolution of function in the "two dinucleotide binding domains" flavoproteins Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome Modulation of the enzymatic efficiency of ferredoxin-NADP(H) reductase by the amino acid volume around the catalytic site.Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide.Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells Using chemical approaches to study selenoproteins-focus on thioredoxin reductases Acetaminophen reactive intermediates target hepatic thioredoxin reductase Cross-linking of thioredoxin reductase by the sulfur mustard analogue mechlorethamine (methylbis(2-chloroethyl)amine) in human lung epithelial cells and rat lung: selective inhibition of disulfide reduction but not redox cycling.Selenoproteins: molecular pathways and physiological roles.Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD).Characterization of protein targets of mammalian thioredoxin reductases.When half is not enough: gene expression and dosage in the 22q11 deletion syndrome.Selenium in thioredoxin reductase: a mechanistic perspective.Investigation of the C-terminal redox center of high-Mr thioredoxin reductase by protein engineering and semisynthesis.Semisynthesis and characterization of mammalian thioredoxin reductase Identification of Michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative activity.No selenium required: reactions catalyzed by mammalian thioredoxin reductase that are independent of a selenocysteine residue.Crystallization and preliminary X-ray studies of ferredoxin-NAD(P)+ reductase from Chlorobium tepidum Why is mammalian thioredoxin reductase 1 so dependent upon the use of selenium?Selenium as an electron acceptor during the catalytic mechanism of thioredoxin reductase Conferring specificity in redox pathways by enzymatic thiol/disulfide exchange reactions.Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione.Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells.Compensating for the absence of selenocysteine in high-molecular weight thioredoxin reductases: the electrophilic activation hypothesis.Identification of acid-base catalytic residues of high-Mr thioredoxin reductase from Plasmodium falciparum.The role of electrostatics in TrxR electron transfer mechanism: A computational approach.

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P2860

Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism.

http://www.wikidata.org/entity/Q34084972

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2005 nî lūn-bûn

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Crystal structures of oxidized ...... ils of the reaction mechanism.

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Crystal structures of oxidized ...... ils of the reaction mechanism.

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Crystal structures of oxidized ...... ils of the reaction mechanism.

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Crystal structures of oxidized ...... ils of the reaction mechanism.

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Crystal structures of oxidized ...... ils of the reaction mechanism.

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Crystal structures of oxidized ...... ils of the reaction mechanism.

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Crystal structures of oxidized ...... ils of the reaction mechanism.

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Crystal structures of oxidized ...... ils of the reaction mechanism.

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Crystal structures of oxidized ...... ils of the reaction mechanism.

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Crystal structures of oxidized ...... ils of the reaction mechanism.

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Anton A Turanov

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Ekaterina I Biterova

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Joseph J Barycki

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Vadim N Gladyshev

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P2860

Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases

An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling

Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme

Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function

The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli

Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

Twists in catalysis: alternating conformations of Escherichia coli thioredoxin reductase

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102

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crystal structure

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