Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination. - Wikidata - wikimedia - TriplyDB

Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination.

Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination.

http://www.wikidata.org/entity/Q34095055

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AID and APOBECs span the gap between innate and adaptive immunity Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer Regulation of Aicda expression and AID activity Etoposide induces nuclear re-localisation of AID An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile.Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Cytidine deaminases: AIDing DNA demethylation?RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle The AID-induced DNA damage response in chromatin.B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.AID induces intraclonal diversity and genomic damage in CD86(+) chronic lymphocytic leukemia cells Targeting of AID-mediated sequence diversification to immunoglobulin genes APOBEC3A can activate the DNA damage response and cause cell-cycle arrest.Complex regulation and function of activation-induced cytidine deaminase.Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells Separation of mutational and transcriptional enhancers in Ig genes.Chronic lung injury by constitutive expression of activation-induced cytidine deaminase leads to focal mucous cell metaplasia and cancer.Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells.Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma.Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase AIDing antibody diversity by error-prone mismatch repair.Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.Oncogenic Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma.Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.Regulation of AID, the B-cell genome mutator.RECQ helicases are deregulated in hematological malignancies in association with a prognostic value Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination.Involvement of activation-induced cytidine deaminase in skin cancer development Activation-Induced Cytidine Deaminase Does Not Impact Murine Meiotic Recombination A critical context-dependent role for E boxes in the targeting of somatic hypermutation.UNG protects B cells from AID-induced telomere loss.BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance.AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination.Different B cell populations mediate early and late memory during an endogenous immune response AID: a riddle wrapped in a mystery inside an enigma.

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Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination.

http://www.wikidata.org/entity/Q34095055

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Widespread genomic breaks gene ...... d by homologous recombination.

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Widespread genomic breaks gene ...... d by homologous recombination.

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Widespread genomic breaks gene ...... d by homologous recombination.

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type

label

Widespread genomic breaks gene ...... d by homologous recombination.

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Widespread genomic breaks gene ...... d by homologous recombination.

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Widespread genomic breaks gene ...... d by homologous recombination.

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Widespread genomic breaks gene ...... d by homologous recombination.

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Widespread genomic breaks gene ...... d by homologous recombination.

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Widespread genomic breaks gene ...... d by homologous recombination.

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Nature Immunology

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Widespread genomic breaks gene ...... d by homologous recombination.

@en

P2093

Eliot Coffey

http://www.w3.org/2001/XMLSchema#string

Jacquelyn Ames

http://www.w3.org/2001/XMLSchema#string

Jane Maynard

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Kathy J Snow

http://www.w3.org/2001/XMLSchema#string

Kevin D Mills

http://www.w3.org/2001/XMLSchema#string

Muneer G Hasham

http://www.w3.org/2001/XMLSchema#string

Nina M Donghia

http://www.w3.org/2001/XMLSchema#string

Robert Y Wilpan

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Yishu He

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P2860

The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2

Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture

XRCC2 is Required for the Formation of Rad51 Foci Induced by Ionizing Radiation and DNA Cross-Linking Agent Mitomycin C

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination

Recombinational DNA repair and human disease

Localization to chromosome 7q36.1 of the human XRCC2 gene, determining sensitivity to DNA-damaging agents

Rad51 expression and localization in B cells carrying out class switch recombination

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

A role for Xrcc2 in the early stages of mouse development

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820-826

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10.1038/NI.1909

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9

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11

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45288482

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20657597

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