N-terminal acetylation of cellular proteins creates specific degradation signals
about
Identification and analysis of the acetylated status of poplar proteins reveals analogous N-terminal protein processing mechanisms with other eukaryotesNatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregationA tobacco etch virus protease with increased substrate tolerance at the P1' positionThe human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4The N-end rule pathwayMouse Dfa is a repressor of TATA-box promoters and interacts with the Abt1 activator of basal transcriptionN-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule PathwaySelective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradationExploring the accessible conformations of N-terminal acetylated α-synucleinRegulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyondStructure and mechanism of non-histone protein acetyltransferase enzymesN-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effectsThe Not4 RING E3 Ligase: A Relevant Player in Cotranslational Quality ControlStructural basis of substrate recognition and specificity in the N-end rule pathwayThe APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27Structure of a Ternary Naa50p (NAT5/SAN) N-terminal Acetyltransferase Complex Reveals the Molecular Basis for Substrate-specific AcetylationN-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein ComplexStructural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation EnzymesPyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in CellsMolecular basis for N-terminal acetylation by the heterodimeric NatA complexImplications for the evolution of eukaryotic amino-terminal acetyltransferase (NAT) enzymes from the structure of an archaeal orthologStructural basis for substrate-specific acetylation of Nα-acetyltransferase Ard1 from Sulfolobus solfataricusPreviously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation.Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic statesN-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases.N-terminal acetylation by NatC is not a general determinant for substrate subcellular localization in Saccharomyces cerevisiaeN-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates.Protein N-terminal acetyltransferases act as N-terminal propionyltransferases in vitro and in vivo.Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiencyExpression of human NAA11 (ARD1B) gene is tissue-specific and is regulated by DNA methylationBiochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defectsComparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-α-acetylation featureshNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencingA Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase NAA10 Ser37Pro mutantProteome-derived peptide libraries allow detailed analysis of the substrate specificities of N(alpha)-acetyltransferases and point to hNaa10p as the post-translational actin N(alpha)-acetyltransferaseA direct, ratiometric, and quantitative MALDI-MS assay for protein methyltransferases and acetyltransferasesCell biology. Metabolic control of cell deathNaked1 antagonizes Wnt signaling by preventing nuclear accumulation of β-cateninLiat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats
P2860
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P2860
N-terminal acetylation of cellular proteins creates specific degradation signals
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
N-terminal acetylation of cellular proteins creates specific degradation signals
@ast
N-terminal acetylation of cellular proteins creates specific degradation signals
@en
N-terminal acetylation of cellular proteins creates specific degradation signals
@nl
type
label
N-terminal acetylation of cellular proteins creates specific degradation signals
@ast
N-terminal acetylation of cellular proteins creates specific degradation signals
@en
N-terminal acetylation of cellular proteins creates specific degradation signals
@nl
prefLabel
N-terminal acetylation of cellular proteins creates specific degradation signals
@ast
N-terminal acetylation of cellular proteins creates specific degradation signals
@en
N-terminal acetylation of cellular proteins creates specific degradation signals
@nl
P2093
P2860
P356
P1433
P1476
N-terminal acetylation of cellular proteins creates specific degradation signals
@en
P2093
Alexander Varshavsky
Anna Shemorry
Cheol-Sang Hwang
P2860
P304
P356
10.1126/SCIENCE.1183147
P407
P577
2010-01-28T00:00:00Z