A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity. - Wikidata - wikimedia - TriplyDB

A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity.

A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity.

http://www.wikidata.org/entity/Q34099015

about

Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease tRNA fragments in human health and disease Influence of naturally-occurring 5â ²-pyrophosphate-linked substituents on the binding of adenylic inhibitors to ribonuclease a: An X-ray crystallographic study Crystal structures of murine angiogenin-2 and -3 - probing ‘structure - function’ relationships amongst angiogenin homologues Crystal structure of human angiogenin with an engineered loop exhibits conformational flexibility at the functional regions of the molecule Chemogenomics: an emerging strategy for rapid target and drug discovery Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening Small-molecule activators of RNase L with broad-spectrum antiviral activity Structural and functional implications of positive selection at the primate angiogenin gene.Genetic selection for peptide inhibitors of angiogenin.Mutational dynamics of murine angiogenin duplicates.Angiogenin: a review of the pathophysiology and potential clinical applications.Emerging role of angiogenin in stress response and cell survival under adverse conditions.Angiogenin-mediated ribosomal RNA transcription as a molecular target for treatment of head and neck squamous cell carcinoma.Antitumoral activity of allosteric inhibitors of protein kinase CK2.Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.Angiogenin promotes tumoral growth and angiogenesis by regulating matrix metallopeptidase-2 expression via the ERK1/2 pathway.Discovery of protein phosphatase 2C inhibitors by virtual screening.Three decades of research on angiogenin: a review and perspective Stem cell function and stress response are controlled by protein synthesis.Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility RNA decay: a novel therapeutic target in bacteria.Neamine inhibits oral cancer progression by suppressing angiogenin-mediated angiogenesis and cancer cell proliferation Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.Angiogenin mediates androgen-stimulated prostate cancer growth and enables castration resistance.Neamine inhibits prostate cancer growth by suppressing angiogenin-mediated rRNA transcription Highly tumorigenic human androgen receptor-positive prostate cancer cells overexpress angiogenin.Angiogenin-stimulated rRNA transcription is essential for initiation and survival of AKT-induced prostate intraepithelial neoplasia.Characterization of the angiogenic activity of zebrafish ribonucleases.Structure of murine angiogenin: features of the substrate- and cell-binding regions and prospects for inhibitor-binding studies.Evidence for novel action at the cell binding site of human Angiogenin revealed by heteronuclear NMR spectroscopy, in silico and in vivo studies.Plexin-B2 Mediates Physiologic and Pathologic Functions of Angiogenin.Levels of soluble angiogenin in chronic myeloid malignancies: clinical implications.Rce1: mechanism and inhibition.NMR study of Met-1 human Angiogenin: (1)H, (13)C, (15)N backbone and side-chain resonance assignment.Statistical analysis of systematic errors in high-throughput screening.

P2860

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P2860

A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity.

http://www.wikidata.org/entity/Q34099015

description

2002 nî lūn-bûn

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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հուլիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

A small-molecule inhibitor of ...... possesses antitumor activity.

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A small-molecule inhibitor of ...... possesses antitumor activity.

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A small-molecule inhibitor of ...... possesses antitumor activity.

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A small-molecule inhibitor of ...... possesses antitumor activity.

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A small-molecule inhibitor of ...... possesses antitumor activity.

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A small-molecule inhibitor of ...... possesses antitumor activity.

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A small-molecule inhibitor of ...... possesses antitumor activity.

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A small-molecule inhibitor of ...... possesses antitumor activity.

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P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

A small-molecule inhibitor of ...... t possesses antitumor activity

@en

P2093

James W Fett

http://www.w3.org/2001/XMLSchema#string

Karen A Olson

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Marc E Key

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Richard Y T Kao

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Robert Shapiro

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P2860

Antiplasmin activity of a peptide that binds to the receptor-binding site of angiogenin

Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin. Alanine derivatives inhibit angiogenin-induced angiogenesis

Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity

Characteristic ribonucleolytic activity of human angiogenin

Characterization of ribonucleolytic activity of angiogenin towards tRNA

Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity

Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography

Cleavage of 3',5'-pyrophosphate-linked dinucleotides by ribonuclease A and angiogenin

Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in neovascularisation during tumour growth

Angiogenesis in cancer and other diseases

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10066-10071

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scholarly article

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10.1073/PNAS.152342999

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15

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99

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Jeremy L. Jenkins

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2002-07-12T00:00:00Z

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11260949

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12118120

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126625

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