Role of CaMKII in RyR leak, EC coupling and action potential duration: a computational model.
about
Calmodulin-dependent protein kinase II: linking heart failure and arrhythmiasCa(2+) current facilitation is CaMKII-dependent and has arrhythmogenic consequencesComputational models reduce complexity and accelerate insight into cardiac signaling networksMicrodomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart Failure.Toward a hierarchy of mechanisms in CaMKII-mediated arrhythmia.Superresolution modeling of calcium release in the heartIntegrative modeling of the cardiac ventricular myocyte.Cardiac myocytes and local signaling in nano-domains.How does stochastic ryanodine receptor-mediated Ca leak fail to initiate a Ca spark?Chronic CaMKII inhibition blunts the cardiac contractile response to exercise trainingMechanistic Investigation of the Arrhythmogenic Role of Oxidized CaMKII in the HeartToward an integrative computational model of the Guinea pig cardiac myocyte.Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells.Computational analysis of the regulation of Ca(2+) dynamics in rat ventricular myocytesCaMKII-dependent activation of late INa contributes to cellular arrhythmia in a model of the cardiac myocyte.Discrete-state stochastic models of calcium-regulated calcium influx and subspace dynamics are not well-approximated by ODEs that neglect concentration fluctuations.Computational approaches to understand cardiac electrophysiology and arrhythmias.The force-frequency relationship: insights from mathematical modeling.Parameter sensitivity analysis of stochastic models provides insights into cardiac calcium sparks.Role of CaMKII and PKA in Early Afterdepolarization of Human Ventricular Myocardium Cell: A Computational Model Study.Modeling CaMKII in cardiac physiology: from molecule to tissue.Modeling CaMKII-mediated regulation of L-type Ca(2+) channels and ryanodine receptors in the heart.Integrative systems models of cardiac excitation-contraction coupling.Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles.Decoding myocardial Ca²⁺ signals across multiple spatial scales: a role for sensitivity analysis.The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias.A model model: a commentary on DiFrancesco and Noble (1985) 'A model of cardiac electrical activity incorporating ionic pumps and concentration changes'.Modeling calcium regulation of contraction, energetics, signaling, and transcription in the cardiac myocyte.Mechanisms of the cyclic nucleotide cross-talk signaling network in cardiac L-type calcium channel regulation.Ryanodine receptor sensitivity governs the stability and synchrony of local calcium release during cardiac excitation-contraction coupling.Does the Goldilocks Principle apply to calcium release restitution in heart cells?Theoretical study of L-type Ca(2+) current inactivation kinetics during action potential repolarization and early afterdepolarizations.
P2860
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P2860
Role of CaMKII in RyR leak, EC coupling and action potential duration: a computational model.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Role of CaMKII in RyR leak, EC ...... ration: a computational model.
@ast
Role of CaMKII in RyR leak, EC ...... ration: a computational model.
@en
Role of CaMKII in RyR leak, EC ...... ration: a computational model.
@nl
type
label
Role of CaMKII in RyR leak, EC ...... ration: a computational model.
@ast
Role of CaMKII in RyR leak, EC ...... ration: a computational model.
@en
Role of CaMKII in RyR leak, EC ...... ration: a computational model.
@nl
prefLabel
Role of CaMKII in RyR leak, EC ...... ration: a computational model.
@ast
Role of CaMKII in RyR leak, EC ...... ration: a computational model.
@en
Role of CaMKII in RyR leak, EC ...... ration: a computational model.
@nl
P2093
P2860
P1476
Role of CaMKII in RyR leak, EC ...... ration: a computational model.
@en
P2093
Joseph L Greenstein
Raimond L Winslow
Yasmin L Hashambhoy
P2860
P304
P356
10.1016/J.YJMCC.2010.07.011
P577
2010-07-23T00:00:00Z