Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic
about
Combination therapies for combating antimicrobial resistanceA crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyraseThe crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove bindingIdentification of unique type II polyketide synthase genes in soilThe TetR family of transcriptional repressors.Towards prediction of metabolic products of polyketide synthases: an in silico analysisThe phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for lifeGenomic and Secondary Metabolite Analyses of Streptomyces sp. 2AW Provide Insight into the Evolution of the Cycloheximide PathwayGenome-guided Investigation of Antibiotic Substances produced by Allosalinactinospora lopnorensis CA15-2(T) from Lop Nor region, China.Metagenomic analysis reveals diverse polyketide synthase gene clusters in microorganisms associated with the marine sponge Discodermia dissoluta.Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase.A natural plasmid uniquely encodes two biosynthetic pathways creating a potent anti-MRSA antibioticCharacterization of the TDP-D-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-D-ravidosamine from thymidine-5-phosphate and glucose-1-phosphate.Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.Identification of the biosynthetic gene cluster for the antibiotic polyketide L-155,175 in Streptomyces hygroscopicus.Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexosesStreptomyces genetics: a genomic perspective.The enzymology of combinatorial biosynthesis.A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesisFunctional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosomeSimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursorsDraft genome sequence of marine Streptomyces sp. strain W007, which produces angucyclinone antibiotics with a benz[a]anthracene skeletonDual control system - A novel scaffolding architecture of an inducible regulatory device for the precise regulation of gene expressionStructural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthasesThe biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites.The evolution of gene collectives: How natural selection drives chemical innovation.Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity.Antibiotics from microbes: converging to kill.From hormones to secondary metabolism: the emergence of metabolic gene clusters in plants.The TetR family of regulators.Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate IntermediateBifunctional antimicrobial conjugates and hybrid antimicrobials.Two transcription factors, CabA and CabR, are independently involved in multilevel regulation of the biosynthetic gene cluster encoding the novel aminocoumarin, cacibiocin.Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action.SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone.Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2Adenylate-forming enzymes of rubradirin biosynthesis: RubC1 is a bifunctional enzyme with aminocoumarin acyl ligase and tyrosine-activating domains.Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891.
P2860
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P2860
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic
@ast
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic
@en
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic
@nl
type
label
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic
@ast
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic
@en
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic
@nl
prefLabel
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic
@ast
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic
@en
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic
@nl
P2093
P2860
P1476
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic
@en
P2093
A Bechthold
C Bihlmaier
H-P Fiedler
J Schimana
S Stockert
P2860
P304
P356
10.1128/AAC.46.5.1174-1182.2002
P407
P577
2002-05-01T00:00:00Z