Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1. - Wikidata - wikimedia - TriplyDB

Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.

Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.

http://www.wikidata.org/entity/Q34107442

about

The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis Lifelong brain health is a lifelong challenge: from evolutionary principles to empirical evidence Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β Late-onset dementia: a mosaic of prototypical pathologies modifiable by diet and lifestyle.Recruiting adaptive cellular stress responses for successful brain ageing.APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions DNA repair deficiency in neurodegeneration.Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease.Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease Selective inhibition by ethanol of mitochondrial calcium influx mediated by uncoupling protein-2 in relation to N-methyl-D-aspartate cytotoxicity in cultured neurons Combined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age-associated DNA damage The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation Evolutionary aspects of human exercise--born to run purposefully.Brain-derived neurotrophic factor as a regulator of systemic and brain energy metabolism and cardiovascular health.Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients.Nuclear depletion of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1) is an indicator of energy disruption in neurons Base excision repair in physiology and pathology of the central nervous system Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan The role of DNA repair in brain related disease pathology.Base excision repair in the mammalian brain: implication for age related neurodegeneration Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair.Induction of chemoresistance by all-trans retinoic acid via a noncanonical signaling in multiple myeloma cells.DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease.BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of apurinic/apyrimidinic endonuclease 1.Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: how important is BDNF?A review on protein-protein interaction network of APE1/Ref-1 and its associated biological functions.The role of DNA base excision repair in brain homeostasis and disease.Oxidative stress-induced CREB upregulation promotes DNA damage repair prior to neuronal cell death protection.Valproic acid potentiates curcumin-mediated neuroprotection in lipopolysaccharide induced rats.Modulation of DNA base excision repair during neuronal differentiation.Brain metabolism in health, aging, and neurodegeneration.Activation of GLP-1 Receptor Enhances Neuronal Base Excision Repair via PI3K-AKT-Induced Expression of Apurinic/Apyrimidinic Endonuclease 1 The Emerging Role of GLP-1 Receptors in DNA Repair: Implications in Neurological Disorders.A reaction to mitochondria in action.Differences in vulnerability to nicotine-induced kindling between female and male periadolescent rats.Neuroprotective effects of rosmarinic acid on ciguatoxin in primary human neurons.

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Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.

http://www.wikidata.org/entity/Q34107442

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Neurons efficiently repair glu ...... on of apurinic endonuclease 1.

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Neurons efficiently repair glu ...... on of apurinic endonuclease 1.

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Neurons efficiently repair glu ...... on of apurinic endonuclease 1.

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Neurons efficiently repair glu ...... on of apurinic endonuclease 1.

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JBC.M109.082883

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Journal of Biological Chemistry

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Neurons efficiently repair glu ...... ion of apurinic endonuclease 1

@en

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Takashi Tadokoro

http://www.w3.org/2001/XMLSchema#string

Vilhelm A Bohr

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P2860

A synaptic model of memory: long-term potentiation in the hippocampus

A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium

Excitotoxic and excitoprotective mechanisms: abundant targets for the prevention and treatment of neurodegenerative disorders

Defective DNA repair and neurodegenerative disease

Negative regulation of the major human AP-endonuclease, a multifunctional protein

The intracellular localization of APE1/Ref-1: more than a passive phenomenon?

Ischemic preconditioning induces XRCC1, DNA polymerase-beta, and DNA ligase III and correlates with enhanced base excision repair

Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.

Mitochondrial membrane potential and the permeability transition in excitotoxicity.

Going APE over ref-1.

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28191-28199

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scholarly article

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10.1074/JBC.M109.082883

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36

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285

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2010-06-23T00:00:00Z

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