Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice.
about
T cell integrin overexpression as a model of murine autoimmunityHuman CD4(+) T-Cells: A Role for Low-Affinity Fc ReceptorsTowards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implicationsEpigenetic Modulation as a Therapeutic Prospect for Treatment of Autoimmune Rheumatic DiseasesEnvironmental exposures and the development of systemic lupus erythematosusPlasticity of DNA methylation in mouse T cell activation and differentiationAssociations between the expression of epigenetically regulated genes and the expression of DNMTs and MBDs in systemic lupus erythematosusCD3Z hypermethylation is associated with severe clinical manifestations in systemic lupus erythematosus and reduces CD3ζ-chain expression in T cells.Murine models of lupus induced by hypomethylated T cellsThe genetics and epigenetics of autoimmune diseases.Epigenetics in human autoimmunity. Epigenetics in autoimmunity - DNA methylation in systemic lupus erythematosus and beyond.Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients.Genomic variants associated with primary biliary cirrhosis.Age-dependent decreases in DNA methyltransferase levels and low transmethylation micronutrient levels synergize to promote overexpression of genes implicated in autoimmunity and acute coronary syndromes.Environmentally induced autoimmune diseases: potential mechanismsInitiation of autoimmunity by a reactive metabolite of a lupus-inducing drug in the thymusAge-associated epigenetic modifications in human DNA increase its immunogenicity.Epigenetics, behaviour, and health.Epigenetics and Autoimmune Thyroid DiseasesDysregulation of T lymphocyte proliferative responses in autoimmunity.The cutaneous pathology of lupus erythematosus: a review.Pathophysiology of translational regulation by microRNAs in multiple sclerosis.Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes.An overview of genetics of paediatric rheumatic diseases.DNA methylation governs the dynamic regulation of inflammation by apoptotic cells during efferocytosis.Pathogenesis of lupus.Abnormal T cell signal transduction in systemic lupus erythematosus.Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations.Transcriptional and epigenetic networks of helper T and innate lymphoid cells.DNA methylation in systemic lupus erythematosus.Improving T-cell therapy for relapsed EBV-negative Hodgkin lymphoma by targeting upregulated MAGE-A4Epigenetics in systemic lupus erythematosus: leading the way for specific therapeutic agentsGenome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus.The real culprit in systemic lupus erythematosus: abnormal epigenetic regulation.Dissecting the molecular mechanisms of TCR zeta chain downregulation and T cell signaling abnormalities in human systemic lupus erythematosus.Decreased T cell ERK pathway signaling may contribute to the development of lupus through effects on DNA methylation and gene expression.Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupusEpigenetics and autoimmune diseases.Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome.CD4(+) T cells epigenetically modified by oxidative stress cause lupus-like autoimmunity in mice.
P2860
Q24806565-FB4C8C14-44F7-42BA-B27B-26D699131CD3Q26745538-3DFD0F52-E099-430E-BDC0-E46E9B0A30F9Q26783490-30EC951D-338D-4B45-8B75-1474E6AFF6F9Q28079715-942BD4C2-580D-4C08-964A-778158008CF1Q28385351-9FB56C1B-0FCF-4EB6-A1FA-D978F9A7EC35Q28727793-0003AD3F-229A-44AA-8A51-5BD91BBBBBB7Q31101708-DCE40661-D211-407B-836E-304F074F9E20Q33437524-2DBA5BF5-855A-4F08-958C-21D6A35133ECQ33621000-9A95A353-1631-4C77-A0E9-05B723D3BCCCQ33642586-D1ED3D7B-974C-481F-97F3-C8A7F830CCC9Q33643660-D18392BC-33C6-44FB-AF30-60B7C07A06D2Q33671906-AE95EFE4-2D13-45AC-BB7E-59CCC34930A6Q33693726-433A5B9B-6CEC-439B-A16A-D457E3610AC6Q33729350-253C74E5-48BF-417B-B959-984BBD1B3878Q33741188-F7D44D3C-6FFD-4CF5-B055-62ADA5043928Q33741226-2DDACC3B-92FE-46B3-8C10-16EFD011DDBEQ33771976-46AA5874-7C3F-42B5-BD7C-7E8556686036Q33848607-A716F580-7E63-466E-8F0E-91B04A87435BQ33849333-C8FC97E7-25B4-48FA-A20A-8D63072D94E9Q34110530-62D752CB-FB34-49DF-9127-923EAA4F14B9Q34135760-46C25BA7-344D-4AF8-A1BA-BA25A2DA6713Q34174676-86586746-1DB4-4E64-961D-03C8BA56AC52Q34356521-C73CE424-B3C5-46DB-9218-CB01A4A56B00Q34363289-F3035B71-E9DE-421A-8BBE-75A1F857F5E7Q34550754-B54F9D49-6909-4F2F-99DC-BBFC4AA5DC13Q34736475-EA828332-A6E9-4AE5-AEFB-94FDE0634631Q34736534-2A010279-9308-4308-9BE9-1D89DCCF703CQ34945629-054AFA00-EF70-40A9-A20E-36863DD8F80FQ35064355-B3B829EF-0890-4AF4-960B-1F46AB7D5DFFQ35083465-C9C4E2AE-93F2-43CE-A388-B4D7EE426540Q35556061-287945AC-CCF2-41DB-87C4-10EFA51566E5Q35620090-37A028C0-7763-4939-B99B-D7FCD31CF22EQ35698898-9AE76DA3-0130-44F5-98B5-E2F2A9F80E29Q35723616-D2D447B3-0F5D-42AD-8838-2AD2E59FEE26Q35809396-D7A94ABD-A4B4-4497-9EFC-FEE8407A1911Q35809419-65B3F651-B650-43CC-80E0-C5A78A4537E2Q35854737-88100E01-776B-45E6-A689-C4AEAC984D5AQ35867015-CFE73612-EEC6-46DF-A2F6-B4D50FA9F304Q35925694-3C40EC7C-ADCE-446D-B0CE-BB7B0C43E500Q35930396-456E306A-A253-4B3E-8925-1B2C45370BD6
P2860
Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice.
description
1993 nî lūn-bûn
@nan
1993 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Treating activated CD4+ T cell ...... ike disease in syngeneic mice.
@ast
Treating activated CD4+ T cell ...... ike disease in syngeneic mice.
@en
Treating activated CD4+ T cell ...... ike disease in syngeneic mice.
@nl
type
label
Treating activated CD4+ T cell ...... ike disease in syngeneic mice.
@ast
Treating activated CD4+ T cell ...... ike disease in syngeneic mice.
@en
Treating activated CD4+ T cell ...... ike disease in syngeneic mice.
@nl
prefLabel
Treating activated CD4+ T cell ...... ike disease in syngeneic mice.
@ast
Treating activated CD4+ T cell ...... ike disease in syngeneic mice.
@en
Treating activated CD4+ T cell ...... ike disease in syngeneic mice.
@nl
P2093
P2860
P356
P1476
Treating activated CD4+ T cell ...... ike disease in syngeneic mice.
@en
P2093
B C Richardson
C E Chrisp
E P Amento
J Gavalchin
K J Johnson
P2860
P356
10.1172/JCI116576
P407
P577
1993-07-01T00:00:00Z