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Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential

Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential

http://www.wikidata.org/entity/Q34110107

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Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects Treatment of Pancreatic Cancer with Pharmacological Ascorbate Moving protons and electrons in biomimetic systems Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications Targeting the redox balance in inflammatory skin conditions Battles with iron: manganese in oxidative stress protection The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways A MALDI-MSI Approach to the Characterization of Radiation-Induced Lung Injury and Medical Countermeasure Development Mn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathways Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria.Novel amphiphilic cationic porphyrin and its Ag(II) complex as potential anticancer agents.Water exchange rates of water-soluble manganese(III) porphyrins of therapeutical potential.CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5.European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).Metal complexes as potential modulators of inflammatory and autoimmune responses.Antioxidant enzymes reduce DNA damage and early activation of valvular interstitial cells in aortic valve sclerosis.Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance Preferential recognition of hydroxyl radical-modified superoxide dismutase by circulating autoantibodies in patients with alopecia areata.Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes.NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment.Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents.Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.Mn (III) tetrakis (4-benzoic acid) porphyrin scavenges reactive species, reduces oxidative stress, and improves functional recovery after experimental spinal cord injury in rats: comparison with methylprednisolone.Angiotensin II and angiotensin-1-7 redox signaling in the central nervous system.Manganese(III) complexes of bis(hydroxyphenyl)dipyrromethenes are potent orally active peroxynitrite scavengers.Stability, disposition, and penetration of catalytic antioxidants Mn-porphyrin and Mn-salen and of methylprednisolone in spinal cord injury.The temporal and spatial profiles of cell loss following experimental spinal cord injury: effect of antioxidant therapy on cell death and functional recovery.Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics Formation of high-order oligomers by a hyperthemostable Fe-superoxide dismutase (tcSOD).An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways.Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death.Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells.Significant in vivo anti-inflammatory activity of Pytren4Q-Mn a superoxide dismutase 2 (SOD2) mimetic scorpiand-like Mn (II) complex.Stable radical content and anti-radical activity of roasted Arabica coffee: from in-tact bean to coffee brew.Genetic ablation of the aryl hydrocarbon receptor causes cigarette smoke-induced mitochondrial dysfunction and apoptosis Strategies for reducing or preventing the generation of oxidative stress Manganoporphyrins and ascorbate enhance gemcitabine cytotoxicity in pancreatic cancer.

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P2860

Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential

http://www.wikidata.org/entity/Q34110107

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2010 nî lūn-bûn

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2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential

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Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential

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Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential

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Antioxidants & Redox Signaling

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Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential

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Ines Batinić-Haberle

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Ivan Spasojević

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P2860

Iron tetrakis (N-methyl-4'-pyridyl) porphyrinato (FeTMPyP) is a potent scavenging antioxidant and an inhibitor of stimulant-induced NF-kB activation of raw 264.7 macrophages

Honokiol, a multifunctional antiangiogenic and antitumor agent

IDH1 and IDH2 mutations in gliomas

Chemistry and antihypertensive effects of tempol and other nitroxides

Hypoxia and oxidative stress in breast cancer. Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer.

Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection

The powerhouse takes control of the cell: is the mitochondrial permeability transition a viable therapeutic target against neuronal dysfunction and death?

A common mechanism of cellular death induced by bactericidal antibiotics

Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)

Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site

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10.1089/ARS.2009.2876

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6

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Julio S Reboucas

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2010-09-01T00:00:00Z

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41121255

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