Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. - Wikidata - wikimedia - TriplyDB

Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.

Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.

http://www.wikidata.org/entity/Q34112535

about

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling Histone Deacetylases and Cardiometabolic Diseases Sirtuins as regulators of metabolism and healthspan MicroRNAs as controlled systems and controllers in non-alcoholic fatty liver disease The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming Energy metabolism in the liver SIRTain regulators of premature senescence and accelerated aging Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism Sirtuins, metabolism, and DNA repair From sirtuin biology to human diseases: an update MicroRNA modulation of cholesterol homeostasis Sirtuins in epigenetic regulation The role of sirtuins in cardiac disease Sirtuins in metabolism, DNA repair and cancer SIRT6 is required for maintenance of telomere position effect in human cells Sirtuin deacylases: a molecular link between metabolism and immunity FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome Nuclear DNA damage signalling to mitochondria in ageing Modulation of microRNA Expression in Subjects with Metabolic Syndrome and Decrease of Cholesterol Efflux from Macrophages via microRNA-33-Mediated Attenuation of ATP-Binding Cassette Transporter A1 Expression by Statins Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-κB-dependent transcriptional activity Liver Patt1 deficiency protects male mice from age-associated but not high-fat diet-induced hepatic steatosis Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.Role of thiazolidinediones, insulin sensitizers, in non-alcoholic fatty liver disease MicroRNAs in metabolism and metabolic disorders NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion.SIRT1 is necessary for proficient telomere elongation and genomic stability of induced pluripotent stem cells.Is SIRT6 Activity Neuroprotective and How Does It Differ from SIRT1 in This Regard?Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.Sirtuins: guardians of mammalian healthspan.Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats.SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress.Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.Sirt1 and Sirt6 mediate beneficial effects of rosiglitazone on hepatic lipid accumulation.MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response.MicroRNAs and lipoproteins: a connection beyond atherosclerosis?Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition.

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P2860

Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.

http://www.wikidata.org/entity/Q34112535

description

2010 nî lūn-bûn

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2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Hepatic-specific disruption of ...... is and triglyceride synthesis.

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Hepatic-specific disruption of ...... is and triglyceride synthesis.

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Hepatic-specific disruption of ...... is and triglyceride synthesis.

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Hepatic-specific disruption of ...... is and triglyceride synthesis.

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Hepatic-specific disruption of ...... is and triglyceride synthesis.

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Hepatic-specific disruption of ...... is and triglyceride synthesis.

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Hepatic-specific disruption of ...... is and triglyceride synthesis.

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Hepatic-specific disruption of ...... is and triglyceride synthesis.

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J.CMET.2010.06.009

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Cell Metabolism

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Hepatic-specific disruption of ...... is and triglyceride synthesis.

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Athanassios Vassilopoulos

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Bin Gao

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Chu-Xia Deng

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Cuiying Xiao

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Guelaguetza Vazquez-Ortiz

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Hyun-Seok Kim

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Ogyi Park

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Rui-Hong Wang

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Sung Hwan Ki

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Tyler Lahusen

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P2860

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

SIRT6 in DNA repair, metabolism and ageing

Genetic pathways that regulate ageing in model organisms

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

Mammalian SIRT1 represses forkhead transcription factors

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224-236

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10.1016/J.CMET.2010.06.009

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3

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12

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2010-09-01T00:00:00Z

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46147452

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20816089

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