ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. - Wikidata - wikimedia - TriplyDB

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.

http://www.wikidata.org/entity/Q34115685

about

Ubc13: the Lys63 ubiquitin chain building machine EMT or EMT-Promoting Transcription Factors, Where to Focus the Light?ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance The emerging molecular machinery and therapeutic targets of metastasis Exosomes-mediate microRNAs transfer in breast cancer chemoresistance regulation DNA damage control: regulation and functions of checkpoint kinase 1 USP7 is a SUMO deubiquitinase essential for DNA replication Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma.Ataxin-3 promotes genome integrity by stabilizing Chk1.Prognostic significance of ZEB1 and ZEB2 in digestive cancers: a cohort-based analysis and secondary analysis.ZEB1 induces ER-α promoter hypermethylation and confers antiestrogen resistance in breast cancer.SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing Profiling global kinome signatures of the radioresistant MCF-7/C6 breast cancer cells using MRM-based targeted proteomics miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13.ZEB1 transcriptionally regulated carbonic anhydrase 9 mediates the chemoresistance of tongue cancer via maintaining intracellular pH.Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation.The ectopic expression of Snail in MDBK cells does not induce epithelial-mesenchymal transition.EMT-associated factors promote invasive properties of uveal melanoma cells Expression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential.Identification of epigenetic factors regulating the mesenchyme to epithelium transition by RNA interference screening in breast cancer cells.The 14-3-3σ/GSK3β/β-catenin/ZEB1 regulatory loop modulates chemo-sensitivity in human tongue cancer The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition RAP80 regulates epithelial-mesenchymal transition related with metastasis and malignancy of cancer.Gas6/Axl Axis Contributes to Chemoresistance and Metastasis in Breast Cancer through Akt/GSK-3β/β-catenin Signaling.ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors.Radiation induces the generation of cancer stem cells: A novel mechanism for cancer radioresistance Epithelial Plasticity During Human Breast Morphogenesis and Cancer Progression.Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation.Twist1 promotes radioresistance in nasopharyngeal carcinoma.Autophagy positively regulates DNA damage recognition by nucleotide excision repair Cancer stem cells: a potential target for cancer therapy.ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types Human papillomavirus status and the relative biological effectiveness of proton radiotherapy in head and neck cancer cells.The long non-coding RNA NEAT1 regulates epithelial to mesenchymal transition and radioresistance in through miR-204/ZEB1 axis in nasopharyngeal carcinoma.AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple Cancers.DNA methylation variations are required for epithelial-to-mesenchymal transition induced by cancer-associated fibroblasts in prostate cancer cells.Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts.Inhibition of cyclin D1 enhances sensitivity to radiotherapy and reverses epithelial to mesenchymal transition for esophageal cancer cells.Down-regulation of FBP1 by ZEB1-mediated repression confers to growth and invasion in lung cancer cells.Elevated Expression of Hepatoma Up-Regulated Protein Inhibits γ-Irradiation-Induced Apoptosis of Prostate Cancer Cells.

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P2860

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.

http://www.wikidata.org/entity/Q34115685

description

2014 nî lūn-bûn

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2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

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2014年の論文

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Nature Cell Biology

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Bisrat G Debeb

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Dahu Chen

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Douglas C Dean

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Han Liang

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Jingsong Yuan

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Jinsong Zhang

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Junjie Chen

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K Kian Ang

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Li Wang

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Mien-Chie Hung

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P2860

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

MDC1 is a mediator of the mammalian DNA damage checkpoint

USP10 regulates p53 localization and stability by deubiquitinating p53

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

The epithelial-mesenchymal transition generates cells with properties of stem cells

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864-875

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10.1038/NCB3013

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9

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