Bifunctional anti-huntingtin proteasome-directed intrabodies mediate efficient degradation of mutant huntingtin exon 1 protein fragments.
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Specific in vivo knockdown of protein function by intrabodiesIntrabodies as neuroprotective therapeuticsPotential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseasesIn-cell intrabody selection from a diverse human library identifies C12orf4 protein as a new player in rodent mast cell degranulationIBC's 23rd Annual Antibody Engineering, 10th Annual Antibody Therapeutics international conferences and the 2012 Annual Meeting of The Antibody Society: December 3-6, 2012, San Diego, CADifferential nuclear localization of complexes may underlie in vivo intrabody efficacy in Huntington's disease.Tau aggregation and its interplay with amyloid-β.Transcriptional dysregulation of inflammatory/immune pathways after active vaccination against Huntington's diseaseBifunctional Anti-Non-Amyloid Component α-Synuclein Nanobodies Are Protective In Situ.Antibody Engineering & Therapeutics 2016: The Antibody Society's annual meeting, December 11-15, 2016, San Diego, CAscyllo-Inositol promotes robust mutant Huntingtin protein degradation.Pharmacological protein targets in polyglutamine diseases: mutant polypeptides and their interactors.Gene-based antibody strategies for prion diseases.Single-chain fragment variable passive immunotherapies for neurodegenerative diseases.Recombinant Antibody Fragments for Neurodegenerative Diseases.Fusion to a highly charged proteasomal retargeting sequence increases soluble cytoplasmic expression and efficacy of diverse anti-synuclein intrabodies.Structure of a single-chain Fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression.Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals.In Vivo Applications of Single Chain Fv (Variable Domain) (scFv) FragmentsTargeted Intracellular Delivery of Antibodies: The State of the ArtProteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson's disease model
P2860
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P2860
Bifunctional anti-huntingtin proteasome-directed intrabodies mediate efficient degradation of mutant huntingtin exon 1 protein fragments.
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
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2011年學術文章
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name
Bifunctional anti-huntingtin p ...... gtin exon 1 protein fragments.
@ast
Bifunctional anti-huntingtin p ...... gtin exon 1 protein fragments.
@en
Bifunctional anti-huntingtin p ...... gtin exon 1 protein fragments.
@nl
type
label
Bifunctional anti-huntingtin p ...... gtin exon 1 protein fragments.
@ast
Bifunctional anti-huntingtin p ...... gtin exon 1 protein fragments.
@en
Bifunctional anti-huntingtin p ...... gtin exon 1 protein fragments.
@nl
prefLabel
Bifunctional anti-huntingtin p ...... gtin exon 1 protein fragments.
@ast
Bifunctional anti-huntingtin p ...... gtin exon 1 protein fragments.
@en
Bifunctional anti-huntingtin p ...... gtin exon 1 protein fragments.
@nl
P2860
P1433
P1476
Bifunctional anti-huntingtin p ...... gtin exon 1 protein fragments.
@en
P2093
Anne Messer
David C Butler
P2860
P304
P356
10.1371/JOURNAL.PONE.0029199
P407
P577
2011-12-22T00:00:00Z