Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture. - Wikidata - wikimedia - TriplyDB

Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture.

Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture.

http://www.wikidata.org/entity/Q34121402

about

Beyond directed evolution--semi-rational protein engineering and design Solvents and sustainable chemistry Microbial enzymes: tools for biotechnological processes Crystal structures of the Chromobacterium violaceumω-transaminase reveal major structural rearrangements upon binding of coenzyme PLP Structural studies ofPseudomonasandChromobacteriumω-aminotransferases provide insights into their differing substrate specificity Crystal Structure of an (R)-Selective ω-Transaminase from Aspergillus terreus The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase fromNectria haematococca Bioretrosynthetic construction of a didanosine biosynthetic pathway Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin The role of distant mutations and allosteric regulation on LovD active site dynamics Crystallographic characterization of the (R)-selective amine transaminase from Aspergillus fumigatus L-allo-threonine aldolase with an H128Y/S292R mutation from Aeromonas jandaei DK-39 reveals the structural basis of changes in substrate stereoselectivity Advances in the directed evolution of proteins.Structural and biochemical characterization of the dual substrate recognition of the (R)-selective amine transaminase from Aspergillus fumigatus Directed divergent evolution of a thermostable D-tagatose epimerase towards improved activity for two hexose substrates Catalytic Promiscuity of Transaminases: Preparation of Enantioenriched β-Fluoroamines by Formal Tandem Hydrodefluorination/Deamination Directed evolution: tailoring biocatalysts for industrial applications Thermostabilization of an esterase by alignment-guided focussed directed evolution Strategies for discovery and improvement of enzyme function: state of the art and opportunities Nitrilases in nitrile biocatalysis: recent progress and forthcoming research Biocatalyst development by directed evolution A roadmap for biocatalysis - functional and spatial orchestration of enzyme cascades Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades Combining a Clostridial enzyme exhibiting unusual active site plasticity with a remarkably facile sigmatropic rearrangement: rapid, stereocontrolled entry into densely functionalized fluorinated phosphonates for chemical biology The evolution of drug design at Merck Research Laboratories.NewProt - a protein engineering portal.Protein engineering: navigating between chance and reason.Use of hydrostatic pressure for modulation of protein chemical modification and enzymatic selectivity.How the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes.Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase Metabolic engineering for the production of natural products.A general strategy for the evolution of bond-forming enzymes using yeast display Combinatorial reshaping of the Candida antarctica lipase A substrate pocket for enantioselectivity using an extremely condensed library.Synthetic biology: regulating industry uses of new biotechnologies.MuteinDB: the mutein database linking substrates, products and enzymatic reactions directly with genetic variants of enzymes.An automated flow for directed evolution based on detection of promiscuous scaffolds using spatial and electrostatic properties of catalytic residues.Catalytic Enantioselective Allylic Amination of Olefins for the Synthesis of ent-Sitagliptin.Directed evolution of RebH for site-selective halogenation of large biologically active molecules.Directed evolution of an ultrastable carbonic anhydrase for highly efficient carbon capture from flue gas.Enzymatic functionalization of carbon-hydrogen bonds.

P2860

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P2860

Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture.

http://www.wikidata.org/entity/Q34121402

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.

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Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.

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Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.

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Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.

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Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.

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Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.

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Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.

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SCIENCE.1188934

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Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.

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Anke Krebber

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Christopher K Savile

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Emily C Mundorff

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Fred J Fleitz

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Gjalt W Huisman

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Gregory J Hughes

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Jacob M Janey

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Jeffrey C Colbeck

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Jeffrey C Moore

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Jos Brands

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P2860

Engineering proteinase K using machine learning and synthetic genes

Semi-synthetic DNA shuffling of aveC leads to improved industrial scale production of doramectin by Streptomyces avermitilis.

Highly efficient asymmetric synthesis of sitagliptin.

Rational engineering of enzyme stability.

Directed evolution of a fucosidase from a galactosidase by DNA shuffling and screening.

Industrial-scale synthesis and applications of asymmetric hydrogenation catalysts.

Biocatalytic reductions: from lab curiosity to "first choice".

Advances in the enzymatic reduction of ketones.

Practical chiral alcohol manufacture using ketoreductases.

Looking forward in pharmaceutical process chemistry.

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305-309

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scholarly article

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10.1126/SCIENCE.1188934

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329

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